Fractional Flow Reserve in Acute Coronary Syndrome: An Updated Systematic Review and Bayesian Meta-Analysis.
Edward T Ha, Haider Shah, Cheng Zhang et al.
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In 30 seconds
This systematic review and Bayesian meta-analysis evaluated the diagnostic performance of fractional flow reserve (FFR) in acute coronary syndrome (ACS) compared to chronic coronary syndrome and angiography-guided strategies. The analysis included 11 trials with 13,029 patients. It found that ACS patients had a 1.9% higher risk of major adverse cardiac events (MACE) at one year compared to chronic coronary syndrome, but no significant difference in MACE rates between FFR-guided and angiography-guided strategies in ACS.
Key findings
- ACS patients had a 1.9% higher risk of MACE at 1 year compared to chronic coronary syndrome.
- No significant difference in 1-year MACE rates between FFR-guided and angiography-guided strategies in ACS (RD=0.9%).
- The analysis included 11 trials with a total of 13,029 patients.
Why it matters
Understanding the performance of FFR in ACS is crucial for optimizing treatment strategies and improving patient outcomes. The findings highlight the increased risk associated with ACS and the need for careful consideration of revascularization approaches.