Effects of exercise on muscle strength and characteristics in rheumatic diseases and sarcopenia: Protocol for the Care for Muscle (C4M) Study.
Maia M Sobejana, Rosa M Korpershoek, Maarten M Steinz et al.
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In 30 seconds
The C4M Study is a randomized controlled trial investigating the effects of strength versus endurance exercise on muscle strength and characteristics in patients with rheumatoid arthritis (RA), osteoarthritis (OA), and sarcopenia (SARC). The study will enroll 69 participants, with the primary outcome being isokinetic muscle strength measured by peak torque. The trial aims to explore how intramuscular pathology influences exercise responses.
Key findings
- The study will enroll 69 patients, with 23 each from RA, OA, and SARC groups.
- Participants will be randomized to either endurance (n=35) or strength exercises (n=34).
- The primary outcome is isokinetic muscle strength measured with the Biodex system.
Why it matters
Understanding the differential effects of exercise types on muscle strength in rheumatic diseases and sarcopenia can inform personalized rehabilitation strategies, potentially improving patient outcomes and quality of life.