Flavonoid-rich foods and vascular functions in healthy adults: a systematic review and meta-analysis of randomized controlled trials.
Arya Ega Prakasa, Ketut Wahyu Adi Saputra, Aloysius Denzel Joshua Reviano et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effects of flavonoid-rich foods on vascular function in 561 healthy adults across 11 randomized controlled trials. The study found a significant improvement in flow-mediated dilation (MD = 1.58%; 95% CI: 0.90 to 2.27%; P < 0.0001) and carotid-femoral pulse wave velocity (MD = -0.28 m s -1; P = 0.0197) in the intervention group compared to controls.
Key findings
- Flavonoid-rich food intake improved flow-mediated dilation by 1.58% compared to controls.
- Carotid-femoral pulse wave velocity decreased by 0.28 m s -1 in the intervention group.
- No significant changes were observed in systolic or diastolic blood pressure.
Why it matters
Understanding the impact of dietary flavonoids on vascular function can inform preventive strategies against cardiovascular diseases, which are a leading cause of mortality. Improved vascular health markers may contribute to better cardiovascular outcomes.