Efficacy of lidocaine spray for pain reduction during rabies immunoglobulin infiltration: a double-blind, randomized, placebo-controlled trial.
VaccineSep 12, 2026 (epub)
Pichat Areeraksakul, Rittirak Othong
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In 30 seconds
This randomized, double-blind, placebo-controlled trial evaluated the efficacy of 10% lidocaine spray for pain reduction during rabies immunoglobulin (RIG) infiltration in 76 adults aged 18-65. The lidocaine group reported significantly lower median pain during needle penetration (25.0 vs 56.5) and RIG infiltration (46.5 vs 77.0) compared to placebo, with p < 0.001 for both comparisons.
Key findings
- Lidocaine spray reduced median pain during needle penetration to 25.0 compared to 56.5 for placebo (p < 0.001).
- Median pain during RIG infiltration was 46.5 in the lidocaine group versus 77.0 in the placebo group (p < 0.001).
- Participant satisfaction was significantly higher in the lidocaine group, scoring 8.0 compared to 6.0 in the placebo group (p < 0.001).
Why it matters
Effective pain management during procedures like RIG infiltration is crucial for patient comfort and compliance. This study demonstrates that lidocaine spray can significantly alleviate pain, potentially improving patient experiences in emergency and infectious disease settings.