Efficacy and Safety of Celecoxib Combined With Jintiange Capsules for the Treatment of Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.
Med Sci MonitSep 14, 2026 (epub)
Jiaxin Zhao, Yongwei Li, Yulin Wang et al.
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In 30 seconds
This randomized, double-blind, placebo-controlled trial assessed the efficacy and safety of celecoxib combined with Jintiange capsules in 120 patients with knee osteoarthritis (KOA). The combination therapy resulted in a 23.5-point reduction in the WOMAC total score, compared to a 13.2-point reduction with celecoxib alone, indicating superior pain relief and functional improvement.
Key findings
- The experimental group had a 23.5-point reduction in WOMAC total score (37.8%) compared to 13.2 points (21.6%) in the control group.
- The WOMAC pain subscale improved by 51.6% in the experimental group versus 33.3% in the control group.
- The experimental group showed a greater reduction in VAS score compared to the control group.
Why it matters
The study highlights the potential benefits of integrating traditional Chinese medicine with conventional NSAID therapy, offering a promising approach to enhance pain management and functional outcomes in patients with knee osteoarthritis.