The effect of antiretroviral therapy adherence on viral load suppression rate among people living with HIV in Ethiopia: A systematic review and meta-analysis.
Desalegn Dawit Assele, Yitayew Ewnetu Mohammed, Abera Gezume Ganta et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the impact of antiretroviral therapy (ART) adherence on viral load suppression among people living with HIV in Ethiopia. The analysis included 39 studies, revealing a pooled ART adherence rate of 79.4% and a viral load suppression rate of 77.5%. Good adherence was associated with a significantly higher likelihood of viral suppression (OR = 6.30).
Key findings
- Pooled prevalence of good ART adherence was 79.4% (95% CI: 74.8%-83.4%).
- Pooled viral load suppression rate was 77.5% (95% CI: 72.5%-81.8%).
- Good ART adherence was associated with a higher likelihood of viral load suppression (OR = 6.30, 95% CI: 4.84-8.19).
- Substantial heterogeneity was observed across studies for both adherence and viral suppression outcomes (I2 > 90%).
Why it matters
Understanding the relationship between ART adherence and viral load suppression is crucial for improving treatment outcomes in HIV care. This evidence underscores the importance of adherence support interventions to enhance virological success and control the HIV epidemic.