Multitarget Pharmacological Mechanisms and Safety Profiles of Six Ethnobotanically Prioritized Indonesian Medicinal Plants for Cardiometabolic Disorders: A Systematic Review.
Febrina A Saputri, Raden M Febriyanti, Zulfan Zazuli et al.
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In 30 seconds
This systematic review evaluated the pharmacological effects and safety of six Indonesian medicinal plants for cardiometabolic disorders. Among the 66 studies analyzed, Gynura procumbens exhibited the most extensive pharmacological activity, including glucose-lowering and anti-inflammatory effects, alongside a favorable safety profile. The review emphasizes the need for standardized research to validate these findings.
Key findings
- Gynura procumbens demonstrated glucose-lowering, lipid-modulating, and anti-inflammatory effects.
- Tithonia diversifolia, Leucaena leucocephala, and Smallanthus sonchifolius showed robust antidiabetic activity but raised toxicity concerns.
- Safety data varied significantly across different plant species and preparations.
- Long-term data on chronic toxicity and reproductive toxicity remain limited.
Why it matters
Understanding the pharmacological mechanisms and safety profiles of these medicinal plants can inform future research and potential therapeutic applications for managing cardiometabolic disorders, although caution is warranted due to variability in safety data.
What to keep in mind
The review highlights substantial heterogeneity in extraction methods and the lack of standardized extracts across studies.