Effects of PERMISSive lung-protective ventilation on outcome in critically ill, invasively ventilated patients (PERMISS): protocol for a feasibility and safety randomised clinical trial.

In 30 seconds

The PERMISS pilot study is a multicenter randomized clinical trial assessing the feasibility and safety of a permissive lung-protective ventilation strategy with a lower respiratory rate in critically ill, invasively ventilated adults. The primary endpoint is the difference in respiratory rate between the permissive and conventional groups from the start of ventilation until extubation.

Key findings

• The primary endpoint is the difference in respiratory rate between the two groups.
• Secondary endpoints include the incidence of unacceptable hypercapnia and severe hypoxaemia.
• The study targets patients with an expected duration of ventilation greater than 24 hours.

Why it matters

Understanding the feasibility and safety of lower respiratory rates in lung-protective ventilation could inform strategies to minimize ventilator-induced lung injury, potentially improving outcomes in critically ill patients.