Association Between Rest-Activity Rhythm and Cardiovascular Disease, Cardiovascular Mortality, and All-Cause Mortality: A Systematic Review and Meta-Analysis.
Fengshuo Chang, Jinhao Xu, Mingdong Guo et al.
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In 30 seconds
This systematic review and meta-analysis examined associations between nonparametric rest-activity rhythm measures and cardiovascular outcomes or mortality in cohort and cross-sectional studies. Seven studies involving 109 365 participants were included. Greater intradaily variability was associated with higher all-cause mortality (HR, 1.05 [95% CI, 1.02-1.09]) and cardiovascular disease prevalence (odds ratio, 1.73 [95% CI, 1.21-2.47]). Lower relative amplitude was associated with higher cardiovascular and all-cause mortality, while interdaily stability was not significantly associated with any outcome.
Key findings
- Higher intradaily variability was associated with all-cause mortality (HR, 1.05 [95% CI, 1.02-1.09]).
- Higher intradaily variability was associated with cardiovascular disease prevalence (odds ratio, 1.73 [95% CI, 1.21-2.47]).
- Lower relative amplitude was associated with cardiovascular mortality (HR, 1.50 [95% CI, 1.13-1.98]) and all-cause mortality (HR, 1.46 [95% CI, 1.27-1.68]).
- Interdaily stability showed no significant association with any assessed outcome.
Why it matters
Rest-activity rhythm measures may capture patterns associated with cardiovascular disease and mortality, complementing established risk assessment. The findings identify rhythm fragmentation and lower rhythm strength as potentially informative markers, but the evidence is observational and does not establish that changing these patterns reduces risk.
What to keep in mind
The review included only seven cohort or cross-sectional studies, so the findings are based on observational evidence and cannot establish causality.