Associations Between Peripheral Blood Inflammatory and Immune Markers and Osteoporotic and Fragility Fractures: A Systematic Review and Meta-Analysis.
Chenyang Li, Chenbing Zhao, Ruhui Fu et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the associations between peripheral blood inflammatory and immune markers and osteoporotic or fragility fractures. Involving 48 observational studies, the analysis found that C-reactive protein/high-sensitivity C-reactive protein was associated with hip fractures (pooled ratio estimate 1.39) and vertebral fractures (2.16).
Key findings
- C-reactive protein/high-sensitivity C-reactive protein was associated with hip fractures (1.39, 95% CI 1.17-1.67).
- C-reactive protein/high-sensitivity C-reactive protein was associated with vertebral fractures (2.16, 95% CI 1.47-3.18).
- Interleukin-6 was associated with hip fractures (1.40, 95% CI 1.15-1.71).
- Tumor necrosis factor-alpha or soluble TNF receptors were associated with hip fractures (1.81, 95% CI 1.34-2.44).
Why it matters
Understanding the relationship between inflammatory markers and fracture risk can help clinicians identify patients at higher risk for osteoporotic fractures, although these markers should not replace established assessment methods.
What to keep in mind
The study's findings are limited by heterogeneity in design, populations, and covariates, which precludes causal interpretations.