Targeting MicroRNAs in doxorubicin-induced cardiotoxicity: A systematic review of transfection studies.
Inderjit Singh Dhami, Satinder Kaur, Gurjit Kaur Bhatti et al.
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In 30 seconds
This systematic review evaluates 24 preclinical studies on microRNAs (miRNAs) involved in doxorubicin-induced cardiotoxicity (DIC). It identifies protective miRNAs like miR-200a and miR-21 that mitigate oxidative stress and apoptosis, while others like miR-140-5p exacerbate cardiotoxicity. The review highlights the potential of miRNAs as therapeutic targets in DIC management.
Key findings
- Protective miRNAs such as miR-200a, miR-21, and miR-29b attenuated oxidative stress and apoptosis.
- MiR-140-5p, miR-128-3p, and miR-34a-5p exacerbated cardiotoxicity by disrupting antioxidant signaling.
- Key pathways involved include the Keap1/Nrf2 axis and PPAR-γ signaling.
Why it matters
Understanding the role of miRNAs in doxorubicin-induced cardiotoxicity could lead to novel therapeutic strategies that enhance cardioprotection during chemotherapy, potentially improving patient outcomes in cancer treatment.
What to keep in mind
The review primarily includes non-human models and lacks integration of clinically translatable delivery strategies.