Disseminated Fusarium infection following cladribine chemotherapy for hairy-cell leukaemia.
Matthew Dandan, Saba Anwer, Adam Kidwell et al.
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Case in brief
A young, healthy patient developed an angioinvasive Fusarium infection following cladribine chemotherapy for hairy cell leukaemia. Despite the absence of consensus guidelines for antifungal prophylaxis in this context, the case underscores the significant morbidity and mortality associated with fusariosis in neutropenic patients. The infection was managed effectively with early recognition and prompt initiation of antifungal treatment.
Diagnostic / clinical pearl
Clinicians should be vigilant for fusariosis in neutropenic patients undergoing cladribine chemotherapy for hairy cell leukaemia, as early antifungal intervention is critical.
Why it matters
This case raises awareness about the potential need for antifungal prophylaxis during hairy cell leukaemia treatment, highlighting a gap in current guidelines that warrants further investigation.