Molecular based diagnostic testing for urinary tract infections: the results remain unclear.
Meghana Reddy, Christina Sze, Bonnie C Prokesch et al.
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In 30 seconds
This systematic review evaluated the impact of molecular-based diagnostic testing for urinary tract infections (UTIs) in adults, focusing on studies published from January 2023 to October 2025. The review included 12 articles, with two randomized controlled trials involving 773 patients. Results indicated that polymerase chain reaction (PCR) testing had superior sensitivity compared to standard urine culture, although specificity was lacking.
Key findings
- Molecular testing showed superior sensitivity compared to standard urine culture.
- PCR testing guided antibiotic therapy, reducing UTI symptoms in the short term.
- Two RCTs included 773 patients, primarily female and over 65 years old.
- 5 out of 10 prospective studies were funded by the companies developing the tests.
Why it matters
Understanding the effectiveness of molecular diagnostics in UTI management is crucial for improving patient outcomes. The findings highlight the potential benefits and limitations of these tests, informing clinical decision-making.