Effect of periprocedural antithrombotic medication on functional outcome and symptomatic intracranial hemorrhage in patients with carotid tandem lesions.
BMJ OpenSep 21, 2026 (epub)
Theodora van Elk, Rianne Vogt, Louise Maes et al.
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In 30 seconds
This post-hoc analysis of the MR CLEAN-MED randomized controlled trial evaluated the impact of periprocedural antithrombotic medication on functional outcomes and symptomatic intracranial hemorrhage in 100 patients with carotid tandem lesions undergoing endovascular treatment. The study found that 34.2% of patients receiving antithrombotic therapy achieved a good functional outcome compared to 60.9% without it (adjusted OR 0.79, 95% CI 0.63 to 0.99).
Key findings
- 34.2% of patients receiving antithrombotic therapy achieved good functional outcomes compared to 60.9% without therapy (adjusted OR 0.79).
- Symptomatic intracranial hemorrhage occurred in 15.8% of patients treated with antithrombotics versus 4.4% without.
- Rates of good functional outcomes were 30.4% with aspirin, 29.2% with heparin, and 41.4% with both.
- The association between antithrombotic therapy and worse functional outcomes was not statistically significant.
Why it matters
Understanding the effects of antithrombotic therapy in patients with carotid tandem lesions is crucial, as it may influence treatment decisions and patient outcomes in acute ischemic stroke management.