Systematic review of cost-effectiveness analyses of weight loss interventions for knee osteoarthritis.
BMJ OpenSep 22, 2026 (epub)
Yue Gao, Hema Mistry, Fatema Dhaif et al.
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In 30 seconds
This systematic review assessed the cost-effectiveness of weight-loss interventions for adults with knee osteoarthritis and obesity. Eight studies were included, revealing that bariatric surgery provided the highest quality-adjusted life years (QALY) gains of 0.81-1.7 at lower incremental cost-effectiveness ratios (ICERs) of £4361 to £19 303 per QALY, compared to diet and exercise programs and pharmacological interventions.
Key findings
- Bariatric surgery yielded QALY gains of 0.81-1.7 with ICERs of £4361 to £19 303 per QALY.
- Combined diet and exercise programs showed QALY gains of 0.05-0.16 with ICERs of £16 915 to £31 305 per QALY.
- Pharmacological interventions had ICERs ranging from £32 265 to £35 832 per QALY.
- Telehealth-only interventions showed mixed evidence with ICERs up to £32 722 per QALY gained.
Why it matters
Understanding the cost-effectiveness of weight-loss interventions is crucial for clinicians managing knee osteoarthritis in obese patients, as it informs treatment decisions and resource allocation in healthcare.