Discovery of mpox virus nucleic acid in bile: a case with multiple coinfections.
Mengze Gan, Jinmei Qin, Xiaoying Qin et al.
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Case in brief
A patient with advanced HIV and multiple coinfections, but no rash, had Monkeypox virus (MPXV) nucleic acid detected in bile. The report establishes that MPXV nucleic acid was detectable in this specimen in this patient; the abstract does not provide further clinical findings or describe how the case resolved. The clinical significance of the detection remains uncertain.
What made this case unusual
MPXV nucleic acid was detected in bile despite the absence of a rash, an unexpected specimen and presentation described by the authors as the first reported detection in human bile.
Diagnostic / clinical pearl
In a rash-free patient with advanced HIV and multiple coinfections, MPXV nucleic acid was detectable in bile; the significance of this finding is not established.