Surveillance of antibiotic-resistant bacteria integrating whole genome sequencing and epidemiological information - a global, systematic review, 2012-2023.
Felix Reichert, Mark Perry, Mirco Sandfort et al.
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In 30 seconds
This systematic review examined global surveillance systems for antibiotic-resistant bacteria (ARB) integrating whole genome sequencing (WGS) and epidemiological data. Out of 13,142 articles, 41 met inclusion criteria, revealing a predominance of short-read sequencing and low levels of epidemiological data collection. The national coverage for carbapenem-resistant Enterobacterales (CRE) was 56%, while methicillin-resistant Staphylococcus aureus (MRSA) coverage was 36%.
Key findings
- 41 surveillance systems were identified from 13,142 articles, focusing on ARB and WGS integration.
- Short-read sequencing was predominantly used across the identified surveillance systems.
- National coverage for MRSA surveillance was 36%, compared to 56% for CRE.
- Low levels of epidemiological data collection were noted, impacting outbreak identification.
Why it matters
Understanding the integration of WGS and epidemiological data in ARB surveillance is crucial for public health. Improved data collection can enhance outbreak detection and inform strategies to combat antibiotic resistance globally.