Stenting Technique and Clinical Outcome in True Bifurcation PCI: Insights From the OCTOBER Trial.
JACC Cardiovasc IntervSep 28, 2026
Clinical ResearchCardiology
Lene Dohn Andreasen, Emil Nielsen Holck, Omeed Neghabat et al.
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In 30 seconds
The OCTOBER trial analyzed 1,201 patients undergoing percutaneous coronary intervention for true bifurcation lesions to compare outcomes of 1-stent versus 2-stent techniques. The study found that a 1-stent technique was associated with a lower 2-year rate of major adverse cardiac events (MACE) at 9.0% compared to 13.9% for the 2-stent technique, with an adjusted hazard ratio of 1.53.
Key findings
- A 1-stent technique had a 2-year MACE rate of 9.0% compared to 13.9% for a 2-stent technique.
- Clinical indication and left main coronary artery bifurcation were strong predictors of 2-stent use.
- OCT-guided DK-crush technique had lower MACE rates compared to angiography-guided DK-crush (HR: 2.42).
- No significant difference in MACE was found based on planned strategy.
Why it matters
Understanding the impact of stenting techniques on clinical outcomes in bifurcation lesions is crucial for optimizing patient management and reducing adverse events. This study provides evidence that may influence decision-making in PCI procedures.