Meta-analysis of Maternal and Fetal Outcomes of Crimean-Congo Hemorrhagic Fever during Pregnancy.
Bahar Donk, Deniz Güllü, Ahmet Mirhan Cırık et al.
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In 30 seconds
This meta-analysis examined the maternal and fetal outcomes of Crimean-Congo hemorrhagic fever (CCHF) in 55 pregnancies. The study found a maternal mortality rate of 28.8% and a fetal loss rate of 57.4%. Notably, maternal mortality increased with gestation, reaching 31.3% in the third trimester, while fetal loss was highest at 85.7% in the first trimester. Ribavirin treatment in the third trimester was linked to lower maternal mortality.
Key findings
- Maternal mortality rate was 28.8% (15/52) across the studied pregnancies.
- Fetal loss occurred in 57.4% (31/54) of cases.
- Maternal mortality reached 31.3% in the third trimester.
- Ribavirin treatment during the third trimester was associated with an odds ratio of 0.33 for lower maternal mortality.
Why it matters
Understanding the severe risks associated with CCHF during pregnancy is crucial for clinicians in endemic areas. The findings emphasize the need for heightened surveillance and tailored management strategies to improve maternal and fetal outcomes.