BK Virus-Associated Hemorrhagic Cystitis in Nontransplanted Children With Hematological Malignancies: A Single-Center Case Series.
Georgina Morón-Cazalilla, Marina Pons-Espinal, Anna Alonso-Saladrigues et al.
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Case in brief
A single-center retrospective series identified six nontransplanted children with leukemia or lymphoma who developed BK virus-associated hemorrhagic cystitis during a 17-year period. Dysuria and visible hematuria were the most common symptoms; one child developed urinary obstruction with acute kidney injury. Median symptom duration was 16 days. Most children received supportive care, and all but one recovered completely without sequelae.
What made this case unusual
The series describes BK virus-associated hemorrhagic cystitis in children with hematological malignancies who had not undergone transplantation, a setting in which the condition is less well described than after hematopoietic stem-cell transplantation.
Diagnostic / clinical pearl
In a nontransplanted child receiving chemotherapy for a hematological malignancy, dysuria and macroscopic hematuria may reflect BK virus-associated hemorrhagic cystitis; monitor for obstruction and acute kidney injury.