Diagnostic Accuracy of Circulating MicroRNAs for Coronary Artery Disease: An Updated Systematic Review and Meta-analysis.
Shankar Biswas, Yashasvi Srivastava, Ayman Hamadttu
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In 30 seconds
This systematic review and meta-analysis evaluated the diagnostic accuracy of circulating microRNAs (miRNAs) for coronary artery disease (CAD) in 3,879 participants across 24 studies. The analysis found a pooled sensitivity of 0.777 and specificity of 0.832, with an area under the curve (AUC) of 0.872, indicating moderate-to-good diagnostic performance. Multi-miRNA panels demonstrated superior accuracy compared to single miRNAs.
Key findings
- Pooled sensitivity for circulating miRNAs in CAD was 0.777 (95% CI: 0.737-0.816).
- Pooled specificity was 0.832 (95% CI: 0.801-0.862).
- The area under the curve (AUC) for diagnostic accuracy was 0.872.
- Multi-miRNA panels had an AUC of 0.901 compared to 0.868 for single miRNAs.
Why it matters
Circulating microRNAs represent a promising non-invasive biomarker for diagnosing coronary artery disease, potentially enhancing early detection and management strategies. Understanding their diagnostic accuracy can inform clinical decision-making and future research directions.