A specialist-led interprofessional weaning program to prevent weaning failure in high-risk patients: the PRiVENT study.
Crit CareSep 30, 2026 (epub)
Franziska C Trudzinski, Benjamin Neetz, Biljana Joveš et al.
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In 30 seconds
The PRiVENT study evaluated a specialist-led interprofessional weaning program for high-risk mechanically ventilated patients in a multicenter, non-randomized trial. Among 349 intervention patients, successful weaning occurred in 58.3%, compared to 51.7% in 1,768 controls. The odds ratio for successful weaning in a propensity score-matched analysis was 2.90 (P < 0.001).
Key findings
- Successful weaning occurred in 58.3% of intervention patients versus 51.7% of controls.
- In propensity score-matched analysis, successful weaning was 58.3% in intervention patients and 46.4% in controls (OR, 2.90; P < 0.001).
- Exploratory analysis showed higher odds of successful weaning in ICU survivors from the intervention group (OR, 2.10; P = 0.026).
- 16.3% of intervention patients were transferred to a specialized weaning center.
Why it matters
This study highlights the potential benefits of a structured, multidisciplinary approach to weaning in high-risk patients, which may improve outcomes and reduce the duration of mechanical ventilation.