Age at Iatrogenic Menopause and Cardiovascular Morbidity and Mortality: A Systematic Review and Meta-Analysis.
Eleni Armeni, Ipek Betul Ozcivit Erkan, Punith Kempegowda
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In 30 seconds
This systematic review and meta-analysis evaluated the cardiovascular morbidity and mortality associated with iatrogenic menopause in 2,617,942 women. It found that iatrogenic menopause was linked to increased all-cause mortality (PHR, 1.08) and cardiovascular events (PHR, 1.25), particularly in women who experienced menopause before age 45. The study highlights the importance of age at menopause as a modifier of risk.
Key findings
- Iatrogenic menopause was associated with a 1.25-fold increased risk of cardiovascular events.
- Women with iatrogenic menopause before age 45 had a 1.20-fold increased risk of cardiovascular mortality.
- Each 5-year increment in age at iatrogenic menopause correlated with a 0.89-fold lower risk of cardiovascular morbidity and mortality.
Why it matters
Understanding the cardiovascular risks associated with iatrogenic menopause, especially at younger ages, is crucial for clinicians to identify and manage at-risk populations effectively. This knowledge can inform patient counseling and risk assessment strategies.