Concordance of Microbiological and Histopathological Examination of Bone Biopsies in Diagnosing Diabetic Foot Osteomyelitis, a Systematic Review.
J Foot Ankle ResOct 3, 2026
Levi Kadiri, Anthony Maher, Andy Bridgen
✦ AI-curated · Sources linked
In 30 seconds
This systematic review evaluated the diagnostic concordance of histopathology and microbiology in bone biopsies from 308 adults with diabetic foot osteomyelitis (DFO). The findings revealed a mean concordance rate of 43.4%, with histopathology showing higher specificity and microbiology demonstrating greater sensitivity, ranging from 70% to 83.9%.
Key findings
- Mean concordance rate of histopathology and microbiology was 43.4%.
- Histopathology showed higher specificity compared to microbiology.
- Microbiology had a sensitivity range of 70% to 83.9%.
- Positive histopathology was linked to increased need for revision surgery or extended antibiotic therapy.
Why it matters
Understanding the concordance between histopathological and microbiological results in DFO can guide clinicians in making informed decisions regarding diagnosis and treatment, potentially improving patient outcomes.