Participant experiences of stopping ART as part of a clinical trial; findings from a qualitative study within the RIO trial in the United Kingdom.
Jesal Gohil, Marcelino Molina, Ali Ahmed et al.
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In 30 seconds
This qualitative study explored the experiences of 20 cisgender men living with HIV who participated in the phase 2 RIO trial, which involved analytical treatment interruptions (ATIs). Participants reported feelings of liberation after stopping ART, but also faced challenges such as anxiety about viral rebound and impacts on personal relationships. The study highlights the importance of regular viral load monitoring and support during ATIs.
Key findings
- Participants found breaking their daily pill routine challenging but felt liberated after stopping ART.
- Weekly viral load testing was preferred for reassurance during the ATI.
- ATIs impacted personal relationships, leading to avoidance of dating and reduced intimacy.
- Restarting ART was difficult but manageable with pre-trial preparation.
Why it matters
Understanding participant experiences in ATI trials is crucial for improving study design and participant retention. Insights into the emotional and relational impacts of ART interruptions can inform ethical practices in clinical research.