Iran's Escherichia coli AMR Landscape (2010-2025): A One Health Systematic Review and Meta-Analysis.
Arezoo Dehghan, Mina Arabian, Zahra Tahmasebi et al.
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In 30 seconds
This systematic review and meta-analysis examined the prevalence of antimicrobial resistance (AMR) in Escherichia coli across humans, animals, foods, and the environment in Iran from 2010 to 2025. A total of 368 studies were analyzed, revealing a high resistance rate of 71.7% for Penicillins and a low rate of 6.8% for Fosfomycins. The findings underscore the urgent need for antimicrobial stewardship.
Key findings
- The highest resistance was found in Penicillins at 71.7% (95% CI: 65.6-76.6).
- Resistance to Ceftizoxime, Ertapenem, Streptomycin, Piperacillin-Tazobactam, and Colistin increased over time.
- 47.2% of E. coli isolates were identified as extended-spectrum β-lactamase-producing (ESBL).
- Among ESBL-producing isolates, the prevalence of bla CTX-M, bla TEM, and bla SHV genes was 68.2%, 58.5%, and 24.4%, respectively.
Why it matters
The rising prevalence of antimicrobial resistance in E. coli poses significant challenges for treatment in both human and veterinary medicine. Understanding these trends is crucial for developing effective antimicrobial stewardship programs and public health policies.