Effects of Benzodiazepines on Heart Failure Outcomes and Adverse Events: A Systematic Review and Meta-Analysis.
Yi-Sin Huang, Galuh Nawang Prawesti, Yi-Chun Chiang et al.
✦ AI-curated · Sources linked
In 30 seconds
This systematic review and meta-analysis evaluated the impact of benzodiazepines (BZDs) on heart failure (HF) outcomes in high-risk populations. Analyzing eleven studies, the results indicated that BZD use was associated with a 41% increased risk of HF incidence (HR = 1.41) and a 29% increased risk of HF hospitalization (HR = 1.29) compared to non-use.
Key findings
- BZD use was linked to a 41% increased risk of HF incidence (HR = 1.41, 95% CI 1.16-1.72).
- BZD use was associated with a 29% increased risk of HF hospitalization (HR = 1.29, 95% CI 1.01-1.65).
- BZD use suggested higher risks of HF hospitalization and rehospitalization compared to antipsychotics and z-drugs.
Why it matters
Understanding the risks associated with benzodiazepine use in patients with heart failure is crucial for clinicians. These findings highlight the need for careful consideration when prescribing BZDs, especially in high-risk populations.
What to keep in mind
Most included studies were observational, indicating that the findings reflect associations rather than causal relationships.