Quercetin in Myocardial Ischemia-Reperfusion Injury: Mechanistic Evidence, Cardioprotective Effects, and Translational Challenges.
Rony Abdi Syahputra, Princella Halim, Sasniwiati Sari Hasibuan et al.
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In 30 seconds
This systematic review assessed the cardioprotective effects of quercetin in myocardial ischemia-reperfusion (I/R) injury, primarily in preclinical studies. Quercetin consistently reduced infarct size and improved cardiac function by modulating oxidative stress and inflammatory pathways. The review included 25 studies, highlighting quercetin's potential but also the need for more clinical research.
Key findings
- Quercetin reduced infarct size and improved cardiac functional parameters across multiple studies.
- It attenuated myocardial injury biomarkers and suppressed oxidative stress and inflammatory signaling.
- Mechanistic actions included modulation of ROS generation and preservation of mitochondrial integrity.
Why it matters
Understanding the cardioprotective effects of quercetin could inform future therapeutic strategies for managing myocardial ischemia-reperfusion injury, a significant challenge in cardiovascular care.
What to keep in mind
Substantial heterogeneity in experimental design and a lack of comparative clinical studies limit the translation of findings.