Ventriculo-arterial coupling in acute heart failure: prognostic and therapeutic insights - a systematic review and meta-analysis of multivariable-adjusted data.
Heart Fail RevOct 6, 2026 (epub)
Dragos Guz, Daniela Filipescu, Beth Davison et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the prognostic significance of non-invasive ventricular-arterial coupling (VAC) in 36,989 patients hospitalized with acute heart failure (AHF). The study found that RV-PA uncoupling was independently associated with increased all-cause mortality (aHR 1.90; 95% CI 1.42-2.56), while LV-Ao uncoupling correlated with higher in-hospital adverse cardiovascular events (aOR 1.70; 95% CI 1.29-2.24).
Key findings
- RV-PA uncoupling was associated with increased all-cause mortality (aHR 1.90; 95% CI 1.42-2.56).
- At 12 months, RV-PA uncoupling showed an aHR of 2.03 (95% CI 1.44-2.85) for mortality.
- LV-Ao uncoupling was linked to higher in-hospital adverse cardiovascular events (aOR 1.70; 95% CI 1.29-2.24).
- Sensitivity analyses confirmed the robustness of these findings.
Why it matters
Understanding the prognostic implications of VAC in AHF can aid clinicians in risk stratification and potentially guide therapeutic decisions, improving patient outcomes.