Multidrug-resistant (MDR) Salmonella Typhi spondylodiscitis with vertebral collapse: a case report.

Future MicrobiolNov 4, 2026 (epub)
Case ReportInfectious DiseasesOrthopedic SurgeryRadiology (Diagnostic)Pathology (Anatomic & Clinical)

Marium Fatima, Maliha Khalid

✦ AI-curated · Sources linked

Case in brief

A 49-year-old woman with diabetes and hypertension developed persistent back pain after enteric fever. Imaging showed spondylodiscitis with vertebral collapse, raising concern for tuberculosis or metastatic disease. Mammography and tuberculosis investigations were negative, and imaging did not establish the cause. Surgical biopsy and culture identified multidrug-resistant Salmonella Typhi, susceptible to imipenem and azithromycin. Targeted antimicrobial therapy was followed by clinical improvement.

What made this case unusual

The spinal infection was caused by multidrug-resistant Salmonella Typhi and presented with vertebral collapse, mimicking tuberculosis or metastasis.

Diagnostic / clinical pearl

When imaging cannot distinguish spinal infection from tuberculosis or malignancy, tissue biopsy and culture may be needed to establish the diagnosis and guide targeted therapy.

Source

PubMed · PMID 43013364

Published in Future Microbiol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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