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1998 articles
October 202624
Impact of HIF-prolyl hydroxylase inhibitors on VEGF expression and vascular adverse events in chronic kidney disease: a meta-analysis of 34 randomized controlled trials.
This meta-analysis of 34 randomized controlled trials assessed VEGF levels and VEGF-related adverse outcomes with hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) in people with chronic kidney disease.
Body Mass Index, Valsartan, and Myocardial Remodeling in Early-Stage Hypertrophic Cardiomyopathy: A Secondary Analysis of the Randomized VANISH Trial.
This post hoc analysis of the randomized, multicenter VANISH trial examined BMI and cardiac remodeling in participants with early-stage hypertrophic cardiomyopathy. Of 171 participants, 52% had elevated BMI.
Effects of gliflozins on bone health of patients with chronic kidney disease: a systematic review.
This systematic review assessed skeletal safety and bone-related metabolic outcomes with sodium-glucose co-transporter-2 inhibitors (SGLT2i) in people with chronic kidney disease, drawing on randomised trials and…
Omega-6 Polyunsaturated Fatty Acids and Peripheral Artery Disease: An Individual Participant-Level Analysis of 9 International Prospective Studies.
This multicohort individual participant-level analysis and meta-analysis examined baseline omega-6 polyunsaturated fatty acids and incident peripheral artery disease (PAD) among 137,704 participants without clinical PAD…
Integrated management of atrial fibrillation with digital health support: a pooled analysis of individual participant data from the mAFA-II and MIRACLE-AF trials.
This pooled individual participant data analysis combined two prospective randomised trials of adults with atrial fibrillation: mAFA-II, which delivered ABC pathway care through a mobile app, and MIRACLE-AF, which used…
EORTC QLQ-C30 symptom components and their functional correlates during adjuvant chemotherapy for early breast cancer: a multivariate analysis. Data from GEICAM/2003-02 study.
This multivariate analysis of data from a multicentre phase III randomised trial examined changes in EORTC QLQ-C30 symptoms and their relationships with functioning among 820 patients with early breast cancer receiving…
Bridging evidence gaps in opioid-sparing postoperative pain control for percutaneous nephrolithotomy: a network meta-analysis identifying optimal strategies.
This systematic review and Bayesian network meta-analysis compared postoperative analgesic strategies in adults undergoing percutaneous nephrolithotomy (PCNL), using randomised controlled trials that assessed pain.
Diagnosis and Management of Nitazene Dependence in Sydney, Australia: A Case Series.
Six young adult men presented to a metropolitan Sydney public hospital in severe opioid withdrawal after nitazene use. Five had regularly vaped products they believed contained cannabinoids or nicotine; toxicology…
Incidence and Influencing Factors of Pain Crisis in Cancer Patients: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed the incidence of pain crisis and associated factors among people with cancer. Seven studies including 1865 patients were analysed; the pooled incidence was 37%.
Effect of web-based education on NIV-related side effects and insomnia severity in COPD patients using home NIV: a randomized controlled trial.
This randomized controlled trial evaluated web-based education about NIV-related side effects and insomnia management in 75 patients with COPD using home noninvasive ventilation.
Genetic Variants in Intracranial Atherosclerotic Disease: A Systematic Review and Targeted Meta-Analysis Highlighting the RNF213 rs112735431.
This systematic review and targeted meta-analysis examined genetic variants associated with intracranial atherosclerotic disease (ICAD) in human studies identified through September 2025.
Tirzepatide-induced pneumatosis intestinalis: a rare but clinically significant gastrointestinal adverse effect.
A 55-year-old man with obesity, type 2 diabetes, hypertension, and obstructive sleep apnea presented with abdominal pain, constipation, and anal fissures while receiving tirzepatide for approximately 1 year; he had lost…
Exercise modality and planned weekly exercise exposure for motor outcomes in Parkinson's disease: a systematic review, Bayesian network meta-analysis, and meta-regression.
This systematic review and Bayesian network meta-analysis synthesized 173 randomized trials of exercise in people with Parkinson’s disease, assessing motor symptoms, balance, walking speed, and Timed Up and Go (TUG).
The effect of a stress ball on pain, anxiety, satisfaction, and treatment continuation during extracorporeal shock wave lithotripsy: a randomized controlled trial.
This prospective, two-arm randomized controlled trial assessed whether using a stress ball during extracorporeal shock wave lithotripsy (ESWL) affected pain, anxiety, satisfaction, and continuation among 50 patients…
Exploring the Neural Mechanisms of Acupuncture Stimulation in Autism Spectrum Disorder: Protocol for a Randomized, Sham-Controlled, Multimodal Neuroimaging Trial.
This protocol describes a randomized, sham-controlled, stratified 2×2 trial designed to examine brain differences associated with autism spectrum disorder (ASD) and the acute neural response to acupuncture.
Comparison of Clinical, Metabolic, and Hormonal Profiles in Obese Versus Lean Women With Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.
This systematic review and random-effects meta-analysis compared clinical, metabolic, and hormonal profiles in obese and lean women with polycystic ovary syndrome (PCOS).
Pilot Randomized Trial of 2 Food Purchasing Interventions in Individuals With Hypertension in New Orleans: An American Heart Association Food Is Medicine Initiative.
This randomized pilot trial compared online and in-store food vouchers among 98 people with uncontrolled hypertension in New Orleans.
Assisted Reproductive Technology and Risk of Congenital Heart Defects in the Offspring: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed congenital heart defect (CHD) risk in offspring conceived through assisted reproductive technology (ART) compared with spontaneous conception.
Association of virulence genes with biofilm formation in clinical Enterococcus faecalis isolates: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis assessed associations between virulence gene carriage and microplate-measured biofilm formation in human clinical Enterococcus faecalis isolates.
Robotic systems in cranial surgery: a systematic review of accuracy, clinical outcomes, and adverse events.
This systematic review examined robotic systems used in cranial neurosurgical procedures and their reported accuracy, clinical outcomes, and adverse events.
The conformation-selective PI3Kδ inhibitor roginolisib in patients with advanced or metastatic cancer, including metastatic uveal melanoma: first-in-human clinical trial.
This first-in-human, phase I dose-escalation and expansion trial evaluated continuous daily roginolisib in patients with solid and haematologic malignancies.
Women's experiences of a medically supervised fasting intervention for infertility: a qualitative study.
Nested within a randomized controlled trial of medically supervised prolonged fluid-only fasting (< 500 kcal/day) for infertility, this qualitative study explored women’s experiences of the intervention.
Outcomes of sequential keratoplasty for bilateral gelatinous drop-like corneal dystrophy: A case report.
A 21-year-old woman of Yemeni ancestry with long-standing bilateral visual impairment, progressive left-eye decline, foreign-body sensation, and a positive family history had previously undergone right penetrating…
A Step-by-Step Protocol for Manual Reduction and Splint Immobilization of Distal Radius Fractures.
A 53-year-old woman presented with a dorsally displaced fracture of the left distal radius. Before reduction, radiographs showed a volar tilt of approximately -15° and radial inclination of approximately 1.74°.
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