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1998 articles

October 202624

Clinical ResearchInfectious Diseases

Evaluation of the Achievement of a Pharmacodynamic Target of Piperacillin-Tazobactam for the Population With Obesity: An Open Randomized Controlled Feasibility Study (TAZO-OBESITY Trial).

The open-label randomized feasibility trial TAZO-OBESITY compared standard with prolonged piperacillin-tazobactam infusions in patients with obesity (BMI ≥30 kg/m²).

Fundam Clin PharmacolOct 23, 2026Read summary
Clinical ResearchEndocrinologyOpen access

Skeletal effects of GLP-1 receptor agonist therapy in adults with overweight or obesity: a systematic review.

This systematic review examined randomized evidence on bone mineral density (BMD) and bone-turnover markers in adults with overweight or obesity receiving GLP-1 receptor agonists.

Arch OsteoporosOct 23, 2026Read summary
Case ReportUrology

Robot-Assisted Radical Prostatectomy in a Post-Enucleation Gland.

A 64-year-old man was found to have right-lobe ISUP grade 3 prostate adenocarcinoma after HoLEP for benign prostatic obstruction. PSA was 0.51 ng/mL, and MRI showed a 0.4 cm PI-RADS 4 lesion.

Int Braz J UrolOct 23, 2026Read case
Case ReportInfectious Diseases

Fatal Occupational Leptospirosis in a Beef Cattle Farmer: Case Report and Epidemiological Investigation.

A 56-year-old beef cattle farmer in Lombardy, Italy, died from occupational leptospirosis. Testing identified a strain of serogroup Javanica, with a microscopic agglutination test titre of 1:3,200 against serovar Poi.

Med LavOct 23, 2026Read case
Clinical ResearchObstetrics & Gynecology

Precancerous cervical lesions and associated factors among HIV-positive women in Southern and Eastern African countries: A systematic review and meta-analysis.

This systematic review and meta-analysis pooled evidence on precancerous cervical lesions (PCCL) and associated factors among women living with HIV in Southern and Eastern Africa.

PLoS OneOct 23, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

Hematological and biochemical responses to three doses of caffeine during the CrossFit® workout: a randomized, double-blind, crossover trial.

This randomized, double-blind, placebo-controlled crossover trial examined hematological and biochemical responses to caffeine during a 17-minute CrossFit® workout in 26 moderately trained athletes.

J Int Soc Sports NutrOct 23, 2026Read summary
Clinical ResearchNeurologyOpen access

Lesion Water Content on CT Predicts 12-Month Outcome and Modifies Thrombectomy Effect in Large-Core Stroke-A Secondary Analysis of the TENSION Trial.

This secondary analysis of the randomized TENSION trial examined whether CT-derived net water uptake (NWU) predicts 12-month outcomes and modifies thrombectomy effects in 198 patients with large-core ischemic stroke.

Transl Stroke ResOct 23, 2026Read summary
Clinical ResearchPsychiatry

Psychoeducation for posttraumatic stress disorder in adults: a systematic review of formats and delivery approaches.

This systematic review synthesized randomized controlled trials of psychoeducation for adults with PTSD, including interventions delivered alone or as a primary component.

Eur J PsychotraumatolOct 23, 2026Read summary
Clinical ResearchHematologyOpen access

The perceptions of hematopoietic stem cell transplantation decision-making in patients with hematologic malignancies: a qualitative systematic review.

This qualitative systematic review synthesized research on how patients with hematologic malignancies perceive decisions about hematopoietic stem cell transplantation (HSCT).

Support Care CancerOct 23, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Protective effect of N-acetylcysteine on oxaliplatin-induced peripheral neuropathy in colorectal cancer: a randomized controlled trial.

This randomized controlled trial evaluated oral N-acetylcysteine (NAC) for preventing oxaliplatin-induced peripheral neuropathy in 46 patients with stage III or high-risk stage II colorectal cancer receiving adjuvant…

Cancer Chemother PharmacolOct 23, 2026Read summary
Case ReportNeurologyOpen access

Neuronal intermediate filament neurologic autoimmunity in a patient with Merkel cell carcinoma receiving pembrolizumab.

A 55-year-old woman with recurrent stage IIIA Merkel cell carcinoma developed vertigo, gait instability, dysarthria, and persistent right hemifacial and cervical spasms after her second pembrolizumab dose.

Neurol SciOct 23, 2026Read case
Clinical ResearchEndocrinology

Search for the glycated hemoglobin target minimizing mortality among people with type 2 diabetes with rare incidence of treatment-related severe hypoglycemia - Epidemiologic analysis of J-DOIT3 randomized controlled trial.

This landmark analysis of the J-DOIT3 randomized controlled trial examined associations between updated HbA1c and cardiovascular outcomes or mortality among people with type 2 diabetes, in a setting where severe…

PLoS OneOct 23, 2026Read summary
Clinical ResearchGeriatrics

A Methodological Framework for a Large Language Model Virtual Companion for Older Adults at Risk of Social Isolation.

This paper presents a methodological framework for developing and evaluating a large language model (LLM)-driven virtual companion for older adults at risk of social isolation.

J Vis ExpOct 23, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Extracorporeal photopheresis for the treatment of steroid-refractory immune related adverse events from immune checkpoint inhibitor therapy: a multi-center phase Ib/II clinical trial.

This prospective, single-arm, non-randomized phase Ib/II multicentre trial evaluated extracorporeal photopheresis (ECP) for steroid-refractory immune-related adverse events (irAEs) in 30 patients receiving immune…

Nat CommunOct 23, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Prophylactic neurectomy versus nerve preservation in open inguinal hernia repair for prevention of chronic postoperative inguinal pain (CPIP): a systematic review and meta-analysis.

This systematic review and meta-analysis assessed prophylactic neurectomy versus nerve preservation in adults undergoing elective open anterior inguinal hernia repair, including 17 randomized trials.

HerniaOct 23, 2026Read summary
Clinical ResearchPediatricsOpen access

Immediate vs delayed extubation after pediatric liver transplantation: a systematic review and meta-analysis.

This systematic review and meta-analysis compared immediate operating-room extubation with delayed extubation after pediatric orthotopic liver transplantation.

Eur J PediatrOct 23, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Association between cancer cachexia and treatment-related adverse outcomes in patients with gastrointestinal cancers: a systematic review and meta-analysis.

This systematic review and meta-analysis examined cohort studies of cancer cachexia and treatment-related outcomes in patients with gastrointestinal cancers.

Support Care CancerOct 23, 2026Read summary
Case ReportNeurology

Intermittent Maple Syrup Urine Disease Presenting With Chronic Demyelinating Polyneuropathy: A Genetically Confirmed DBT-Related Case.

A female patient with intermittent maple syrup urine disease (MSUD), genetically confirmed by compound heterozygous pathogenic DBT variants, had recurrent ataxic episodes from early childhood.

J Peripher Nerv SystOct 23, 2026Read case
Clinical ResearchGastroenterology

Impact of YAQ001 on the Gut Microbiome, Permeability and Markers of Systemic Inflammation in Patients With Cirrhosis.

This double-blind randomised controlled substudy examined YAQ001’s effects on the gut microbiome and exploratory markers of gut permeability and systemic inflammation in 28 patients with cirrhosis.

Liver IntOct 23, 2026Read summary
Case ReportPsychiatry

Psychopathological and neuropsychological sequelae in children victimised by intimate partner violence: a clinical case series.

A clinical case series assessed four children aged 5–9 with documented exposure to intimate partner violence, including witnessing violence and, in some cases, direct abuse.

Eur J PsychotraumatolOct 23, 2026Read case
Clinical ResearchNephrology

Effects of E-Coach-Based Chronic Disease Management on Self-Management, Quality of Life, and Mental Health in Maintenance Hemodialysis Patients.

This randomized controlled trial evaluated a WeChat-based E-Coach programme in 96 patients receiving maintenance hemodialysis, comparing usual care plus E-Coach with usual care alone.

J Vis ExpOct 23, 2026Read summary
Case ReportMedical GeneticsOpen access

Delayed diagnosis of MEN1 after kidney transplantation: unrecognized pre-transplant features and implications for clinical practice.

A 68-year-old man with end-stage renal disease underwent living-donor kidney transplantation and had persistent hypercalcemia afterward.

CEN Case RepOct 23, 2026Read case
Clinical ResearchNeurologyOpen access

STN-SNr co-stimulation in Parkinson's disease: a systematic review and meta-analysis of motor and freezing-of-gait outcomes.

This systematic review and meta-analysis assessed whether adding substantia nigra pars reticulata stimulation to subthalamic nucleus deep brain stimulation improves motor function or freezing of gait in people with…

Neurol SciOct 23, 2026Read summary
Clinical ResearchDermatologyOpen access

Fractional CO₂ laser combined with intradermal and topical platelet-rich plasma for hypertrophic scars: a randomized controlled trial.

This prospective, randomized, assessor-blinded trial compared fractional CO₂ laser plus intradermal and topical platelet-rich plasma (PRP) with laser plus saline in 120 patients with hypertrophic scars.

Lasers Med SciOct 23, 2026Read summary

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