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1998 articles

October 202624

Clinical ResearchInfectious DiseasesOpen access

Initial HIV Therapy for Adults and Treatment-Associated Weight Gain: The Opti-DOR Randomized Clinical Trial.

The Opti-DOR open-label, noninferiority randomized trial compared two initial antiretroviral regimens in 600 ART-naive adults at two South African sites; 99.5% of participants were Black African.

JAMAOct 20, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Comparative perioperative and oncological outcomes of the da Vinci Xi versus Si robotic surgical systems in rectal cancer surgery: a systematic review and meta-analysis.

This systematic review and meta-analysis compared perioperative and oncological outcomes with da Vinci Xi versus Si systems in rectal cancer surgery.

J Robot SurgOct 20, 2026Read summary
Clinical ResearchObstetrics & GynecologyOpen access

Effectiveness and safety of adjunct interventions for external cephalic version in breech presentation: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed adjunct and procedural strategies for external cephalic version (ECV) in pregnant women with breech presentation, drawing on 10 randomised controlled trials with 2,745…

Rev Bras Ginecol ObstetOct 20, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Entinostat plus exemestane for hormone receptor-positive advanced breast cancer: long-term overall survival results from the EOC103A3101 randomized controlled trial.

This randomized controlled trial assessed long-term overall survival with entinostat plus exemestane versus placebo plus exemestane in 354 patients with hormone receptor-positive, HER2-negative advanced breast cancer…

Signal Transduct Target TherOct 20, 2026Read summary
Case ReportNeurology

Child Neurology: Neonatal Management of Tyrosine Hydroxylase Deficiency: How Early Is Early Enough?

Two preterm neonates from unrelated families with a known family history of tyrosine hydroxylase deficiency were diagnosed early. Both began levodopa/carbidopa treatment during the neonatal period.

NeurologyOct 20, 2026Read case
Clinical ResearchOrthopedic Surgery

A Systematic Review of Complications Following Elective Foot and Ankle Surgery.

This systematic review synthesized complication profiles and risk factors in adults undergoing elective foot and ankle surgery.

J Foot Ankle ResOct 20, 2026Read summary
Case ReportMedical GeneticsOpen access

Phenotypic variability in Arboleda-Tham syndrome: a report of a polish patient with a pathogenic KAT6A variant.

A 6-year-old boy born to healthy parents had global developmental delay, with milestones reached substantially later than expected. Diagnostic evaluation began at 18 months.

Mol Biol RepOct 20, 2026Read case
Case ReportHematology

Teclistamab Induced a Profound Hematologic Response in Light Chain Deposition Disease With Probable Cardiac Involvement.

A 63-year-old man had κ-light chain deposition disease involving the kidneys, with probable cardiac involvement. After an initial response to daratumumab-pomalidomide-dexamethasone, he developed hematologic relapse.

Hematol OncolOct 20, 2026Read case
Clinical ResearchPediatrics

The impact of recreational beach tennis associated with nutritional counseling on cardiometabolic risk factors in adolescents: a randomized clinical trial.

This 12-week randomized clinical trial compared recreational beach tennis alone with beach tennis plus nutritional counseling in 40 adolescents aged 11–14 years.

Arch Endocrinol MetabOct 20, 2026Read summary
Clinical ResearchPediatricsOpen access

Neonatal gastric perforation: a systematic review and meta-analysis of clinical characteristics, risk factors, surgical management and outcomes.

This systematic review and meta-analysis examined clinical features, risk factors, surgical management and outcomes of neonatal gastric perforation using observational studies of neonates aged 28 days or younger.

Pediatr Surg IntOct 20, 2026Read summary
Clinical ResearchRheumatologyOpen access

The Effect of Mindfulness-Based Cognitive Therapy on Kinesiophobia in Older Adults with Chronic Knee Osteoarthritis: A Randomized Controlled Trial.

This randomized controlled trial evaluated mindfulness-based cognitive therapy (MBCT) for kinesiophobia in 56 older adults with chronic knee osteoarthritis in Kashan, Iran.

Clin Interv AgingOct 20, 2026Read summary
Clinical ResearchPsychiatry

Incorporating Data From Text Messages and Email Into Psychotherapy: Randomized Controlled Trial.

This randomized controlled trial examined whether reviewing personalized text-message data before psychotherapy sessions improved outcomes for 101 adults and older adults receiving treatment for primary depression or…

JMIR Ment HealthOct 19, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Loop Taping for Heel Fat Pad Syndrome: A Crossover Pilot Randomized Controlled Trial.

This two-period crossover pilot randomized controlled trial assessed loop taping in adults with heel fat pad syndrome, comparing it with control taping in randomized order.

J Foot Ankle ResOct 19, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Tranexamic acid in laparoscopic sleeve gastrectomy: bleeding control amid thrombotic concerns and hemodynamic instability: a randomized double-blinded clinical trial.

This randomized, double-blinded clinical trial assessed tranexamic acid (TXA) for perioperative bleeding prevention in 185 patients with morbid obesity undergoing elective laparoscopic sleeve gastrectomy.

Acta Cir BrasOct 19, 2026Read summary
Clinical ResearchCardiology

Coronary artery disease management in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation: a systematic review and meta-analysis of randomised controlled trials.

This systematic review and meta-analysis of randomised trials compared coronary revascularisation strategies in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI).

EuroInterventionOct 19, 2026Read summary
Case ReportNeurologyOpen access

Cerebrospinal fluid positive for SARS-CoV-2 associated with neurological manifestations and proteome alterations in a multiple myeloma patient.

A 67-year-old woman with multiple myeloma and recent exposure to a person with COVID-19 developed rapidly progressive dysarthria, dysphagia, and hypoesthesia without respiratory symptoms.

Neurol SciOct 19, 2026Read case
Clinical ResearchPsychiatry

Characterizing Behavioral Engagement in Smartphone Cognitive Behavioral Therapy for Obsessive Compulsive Disorder: Secondary Analysis of a Randomized Controlled Trial.

This exploratory secondary analysis of a 12-week randomized controlled trial examined behavioral engagement with smartphone cognitive behavioral therapy for obsessive compulsive disorder (OCD) in 60 participants.

JMIR Form ResOct 19, 2026Read summary
Clinical ResearchPsychiatry

The effectiveness of meaning-based interventions in reducing suicide-related vulnerability: A systematic review.

This systematic review examined whether meaning-based interventions affect suicide-related outcomes and how their effects may operate.

Palliat Support CareOct 19, 2026Read summary
Clinical ResearchFamily Medicine

AI-Based Clinical Decision Support Systems in Primary Care: Systematic Review of Clinical Implementation.

This systematic review assessed the effectiveness and safety of AI-based clinical decision support systems (AI-CDSSs) used by health professionals in primary care, compared with usual care or non-AI decision support.

J Med Internet ResOct 19, 2026Read summary
Clinical ResearchNeurology

Association of dietary choline intake with cognitive decline and related outcomes: a systematic review and dose-response meta-analysis of observational studies.

This systematic review and dose-response meta-analysis examined observational evidence on dietary choline intake and cognitive decline or related outcomes.

Food FunctOct 19, 2026Read summary
Clinical ResearchPreventive Medicine / Public Health

Walnut consumption improves mood and is associated with increased urinary excretion of 5-hydroxyindoleacetic acid and urolithins in a randomized crossover trial.

This 18-week open-label randomized crossover trial assessed whether daily walnut consumption affected mood and urinary metabolites in 31 healthy young adults.

Food FunctOct 19, 2026Read summary
Clinical ResearchOrthopedic Surgery

Metal Hypersensitivity Reactions Following Spinal Implants: A Systematic Review.

This systematic review examined clinical presentation, diagnostic approaches, and outcomes of metal hypersensitivity after spinal implant surgery in adults.

JBJS RevOct 19, 2026Read summary
Clinical ResearchPediatricsOpen access

Paediatric Helicobacter pylori infection and allergic and inflammatory diseases: a contemporary systematic review with meta-analysis.

This systematic review and meta-analysis assessed recent evidence on Helicobacter pylori infection and allergic or immune-mediated diseases in children.

Eur J PediatrOct 19, 2026Read summary
Case ReportDermatology

Oral mucous membrane pemphigoid as a window to systemic autoimmunity: two cases associated with rheumatoid arthritis and Sjögren's disease.

Two women presented with oral mucous membrane pemphigoid (MMP) in the setting of systemic autoimmunity. A 68-year-old woman with longstanding rheumatoid arthritis had recurrent oral ulcerations confirmed as MMP on…

Einstein (Sao Paulo)Oct 19, 2026Read case

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