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2000 articles

October 202624

Clinical ResearchPreventive Medicine / Public Health

A Single Exercise Session Elicits a Transient Kynurenine Metabolic Signature in Health and Disease: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis examined acute changes in circulating tryptophan (TRP) and kynurenine-pathway metabolites after a single exercise session.

FASEB JOct 14, 2026Read summary
Clinical ResearchOrthopedic Surgery

Antibiotic-Loaded Hydrogel, Calcium Bead, and Cement in Periprosthetic Joint Infection Following Hip-Knee Arthroplasty: A Systematic Review and Meta-Analysis of Commercially Available Products.

This systematic review and meta-analysis compared defensive antibacterial coating (DAC), calcium sulfate beads, and antibiotic-loaded bone cement for preventing or managing periprosthetic joint infection after total hip…

J Am Acad Orthop Surg Glob Res RevOct 14, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Anxiety in patients with cancer and emergency department use: a systematic review.

This systematic review examined whether anxiety is associated with subsequent emergency department (ED) use among adults with cancer.

Support Care CancerOct 14, 2026Read summary
Clinical ResearchAnesthesiology

Pericapsular Nerve Group Block Versus Femoral Nerve Block for Analgesia in Newly Admitted Patients With Hip Fractures: A Randomized Controlled Trial.

This randomized controlled trial compared preoperative pericapsular nerve group (PENG) block with femoral nerve block (FNB) in 60 newly admitted patients with hip fractures.

Clin J PainOct 14, 2026Read summary
Clinical ResearchPhysical Medicine & RehabilitationOpen access

Immediate effects of spinal manipulation, exercise therapy, and open-label placebo on lifting performance and pain in individuals with chronic non-specific back pain: a motion laboratory-based crossover randomized controlled trial.

This motion-laboratory crossover randomised controlled trial examined immediate effects of spinal manipulation (SMT), exercise therapy (ET), and open-label placebo (OLP) on lifting and pain in 50 individuals with…

Chiropr Man TherapOct 14, 2026Read summary
Clinical ResearchPsychiatry

An Internet-Based Cognitive-Behavioral Program, With Telephone Support, Improves Pain, Disability and Emotional Well-Being in Adults With Chronic Pain: Randomized Controlled Trial of the Pain Course With 2-Year Follow-Up.

This randomised controlled trial evaluated an internet-delivered, cognitive-behavioral Pain Course with clinician support in adults with chronic pain living in Ireland.

Clin J PainOct 14, 2026Read summary
Case ReportPhysical Medicine & RehabilitationOpen access

Surgery to treat autonomic dysreflexia due to cubital tunnel syndrome in cervical spinal cord injury: a case report.

A 74-year-old woman with remote C6 spinal cord injury (AIS B) developed recurrent autonomic dysreflexia episodes that had not responded to standard measures.

Spinal Cord Ser CasesOct 14, 2026Read case
Clinical ResearchPlastic Surgery

Multiple-Staged Versus Single-Stage Surgical Excision for the Reconstruction of Congenital Melanocytic Nevi: A Meta-Analysis of Efficacy and Safety.

This meta-analysis compared multiple-staged with single-stage excision and reconstruction for congenital melanocytic nevi (CMN). It pooled seven retrospective cohort or clinical controlled studies involving 578 patients.

Ann Ital ChirOct 14, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Immune biomarkers of response and resistance to ipilimumab and nivolumab in metastatic castration-resistant prostate cancer.

The multicenter phase II AMADEUS prostate expansion cohort evaluated escalating ipilimumab doses with nivolumab in 32 patients with metastatic castration-resistant prostate cancer, assessing disease control, tumoral CD8…

Sci AdvOct 14, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Camrelizumab plus chemotherapy as induction therapy followed by concurrent chemoradiotherapy and camrelizumab consolidation in limited-stage small cell lung cancer: a randomized phase II trial.

This randomized phase II trial compared a camrelizumab-based induction and consolidation strategy with induction chemotherapy followed by concurrent chemoradiotherapy (CRT) alone in previously untreated patients with…

Signal Transduct Target TherOct 14, 2026Read summary
Clinical ResearchGeneral Surgery

Modified LIFT via a Lateral Approach Versus Standard LIFT for Transsphincteric Anal Fistula: A Prospective Randomized Study.

This single-center prospective randomized study compared modified ligation of the intersphincteric fistula tract (LIFT) via a lateral approach with standard LIFT in adults with MRI-confirmed transsphincteric anal…

Ann Ital ChirOct 14, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Routine versus postoperative CRP/CT guided selective diverting ileostomy after laparoscopic low anterior resection for rectal cancer: a comparative randomized controlled trial.

This randomized controlled trial compared postoperative CRP/CT-guided selective diversion with routine diverting ileostomy in 200 patients with stage II or III middle or lower rectal cancer undergoing laparoscopic low…

BMC SurgOct 14, 2026Read summary
Case ReportNeurology

A 35-Year-Old Woman With Multiple Sclerosis and a New Atypical Thalamic Lesion: A Case Report From the National Multiple Sclerosis Society Case Conference Proceedings.

A 35-year-old woman with multiple sclerosis developed an enlarging thalamic lesion. Although new or enlarging lesions in MS can indicate disease activity, the lesion was ultimately diagnosed as a diffuse midline glioma…

Neurol Neuroimmunol NeuroinflammOct 14, 2026Read case
Clinical ResearchOncology (Medical)Open access

A comprehensive review of European clinical practice guidelines on psychological and cognitive assessment and support for cancer patients and their families.

This systematic review mapped European clinical practice guidelines and recommendations published in the preceding 15 years on psychological and cognitive assessment and support for people with cancer and their…

Support Care CancerOct 14, 2026Read summary
Clinical ResearchGastroenterology

Patient-reported and caregiver-reported outcomes in refractory ascites secondary to cirrhosis: A systematic review and meta-analysis.

This systematic review and meta-analysis examined patient- and caregiver-reported outcomes in refractory ascites (RA) secondary to advanced chronic liver disease.

Hepatol CommunOct 14, 2026Read summary
Clinical ResearchObstetrics & Gynecology

Clinical, economic, and health-related quality of life impact of intrapartum group B Streptococcus (GBS) tests for prevention of neonatal GBS infection: a systematic literature review.

This systematic literature review assessed the clinical performance, economic impact, and health-related quality of life associated with intrapartum group B Streptococcus (GBS) screening.

J Matern Fetal Neonatal MedOct 13, 2026Read summary
Clinical ResearchInfectious Diseases

Epigenetic insights into anti-tuberculosis drug-induced liver injury: A systematic review of DNA methylation as a potential biomarker.

This systematic review assessed whether DNA methylation patterns are associated with susceptibility to anti-tuberculosis drug-induced liver injury (ATDILI).

Eur J PharmacolOct 13, 2026Read summary
Clinical ResearchInfectious Diseases

Safety and immunogenicity of Thailand Government Pharmaceutical Organization (GPO) produced, COVID-19 vaccine, 10 μg HXP-GPOVac: A Phase III, double-blind, randomized trial in comparison with VAXZEVRIA.

This phase III, double-blind, randomized active-controlled trial compared a single dose of Thailand-produced HXP-GPOVac with VAXZEVRIA in healthy or clinically stable Thai adults who had completed a two-dose COVID-19…

VaccineOct 13, 2026Read summary
Clinical ResearchNeurologyOpen access

Long-Term Quantitative MRI and Quality-of-Life After Endovascular Therapy in Acute Ischemic Stroke - A MR CLEAN-NO IV Substudy.

This long-term substudy of the MR CLEAN-NO IV randomised trial examined quantitative MRI and quality of life three years after acute ischaemic stroke.

Transl Stroke ResOct 13, 2026Read summary
Clinical ResearchNephrology

Haemodiafiltration, haemofiltration and haemodialysis for adults with kidney failure.

This Cochrane systematic review and meta-analysis assessed randomised trials comparing convective dialysis (haemofiltration, haemodiafiltration or acetate-free biofiltration) with diffusive haemodialysis or expanded…

Cochrane Database Syst RevOct 13, 2026Read summary
Clinical ResearchPhysical Medicine & Rehabilitation

Refining Home-Based Squat Training: The Role of Hip Adduction in Improving Neuromuscular Control for Clinically Diagnosed Patellofemoral Pain Syndrome.

This randomized controlled trial compared an 8-week home-based squat program with and without hip adduction in 30 participants with clinically diagnosed patellofemoral pain syndrome (PFPS); both groups also performed…

Med Sci MonitOct 13, 2026Read summary
Case ReportNeurosurgery

Stroke thrombectomy of a mural thrombus in a severe dolichoectatic basilar artery with double parallel large stent retrievers and Sofia 88.

An older adult presented with severe acute ischemic stroke from a mural thrombus on the posterior wall of the mid-basilar artery.

J Neurointerv SurgOct 13, 2026Read case
Clinical ResearchOtolaryngology (ENT)

Adenotonsillectomy for children with mild sleep-disordered breathing: who benefits?

This secondary analysis of a 12-month, multicentre randomised trial examined children aged 3.0–12.9 years with mild sleep-disordered breathing, comparing early adenotonsillectomy (eAT) with watchful waiting and…

SleepOct 13, 2026Read summary
Clinical ResearchPediatricsOpen access

Daily Zinc Supplementation for Infection Prevention in Children With Sickle Cell Anemia: The ZIPS-2 Randomized Clinical Trial.

The ZIPS-2 randomized, double-blind, placebo-controlled trial evaluated daily zinc for infection prevention in children aged 1 to 4.99 years with sickle cell anemia in Uganda.

JAMAOct 13, 2026Read summary

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