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1999 articles
October 202624
Efficacy and safety of baxdrostat in the management of uncontrolled hypertension: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed baxdrostat versus placebo in randomized controlled trials involving patients with uncontrolled hypertension.
Focal Epithelial Hyperplasia in a Somali Child: A Case Report and Review of Management with Topical Imiquimod.
An 8-year-old Somali girl had a 3.5-year history of asymptomatic, progressively increasing oral lesions. Examination showed multiple soft, flat-topped verrucous papules on the lower labial, buccal and lingual mucosa and…
Feasibility and Activity of Concurrent Neoadjuvant Chemotherapy and Radiotherapy in Patients with High-risk Soft-Tissue Sarcoma.
This analysis of the international, randomized phase III ISG-STS 1001 trial assessed concurrent epirubicin–ifosfamide chemotherapy (EI) and radiotherapy in patients with localized, high-risk soft-tissue sarcoma.
Giant Cystic Lymphangioma of the Transverse Mesocolon in a 7-Year-Old Child: A Case Report.
A 7-year-old girl presented with several weeks of vomiting, abdominal pain and progressive distension. Examination found a large abdominal mass; laboratory results were unremarkable.
Prognostic value of measuring LSC frequency in AML: a systematic review and meta-analysis.
This systematic review and reconstructed individual patient data meta-analysis assessed whether leukemia stem cell (LSC) measurements predict outcomes in patients with acute myeloid leukemia at diagnosis or in…
Ponatinib-Blinatumomab or Imatinib-Chemotherapy for Adult Ph-Positive ALL.
This multicenter, phase 3 randomized trial compared frontline ponatinib plus blinatumomab with imatinib plus chemotherapy in adults with Philadelphia-positive acute lymphoblastic leukemia.
Psychoeducational interventions for children and adolescents with potentially traumatic experiences: a systematic review.
This systematic review examined stand-alone psychoeducational interventions for children and adolescents exposed to potentially traumatic experiences, including interventions delivered directly or through caregivers.
Primary Hepatic Neuroendocrine Neoplasms: Systematic Review and Expert Pathologist Reappraisal Using the WHO 6th Edition Framework.
Primary hepatic neuroendocrine neoplasms (PHNENs) are exceedingly rare. Published evidence often lacks adequate clinicopathological support for a primary hepatic origin and uses inconsistent historical terminology.
Multimodal assessment of exceptional responders refines subtyping-directed precision treatment in HR+/HER2- breast cancer.
This clinical-trial analysis examined whether multimodal tumour and clinical features could clarify exceptional responses to subtype-directed treatment in locally advanced HR+/HER2− breast cancer.
Key Predictors of Cerebral Vasospasm Following Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined observational evidence on factors associated with cerebral vasospasm after subarachnoid hemorrhage (SAH).
TRANSFORM-1 phase 3 study: efficacy and safety of navitoclax plus ruxolitinib in patients with untreated myelofibrosis.
TRANSFORM-1 was a multicentre, randomised phase 3 trial comparing navitoclax plus ruxolitinib with placebo plus ruxolitinib in Janus kinase inhibitor-naïve adults with intermediate-2 or high-risk myelofibrosis.
3D-printed reduction guide with hinge and window. Design for conservative veneer preparations.
A 36-year-old woman sought improvement of her smile. Existing ceramic veneers from the maxillary right to left canine showed staining and crack lines, with mild gingival recession around the restored teeth.
A phase 2 trial of daratumumab monotherapy for patients with newly diagnosed cardiac stage IIIb AL amyloidosis.
This prospective, multicentre phase 2 trial evaluated daratumumab monotherapy in previously untreated patients with measurable AL amyloidosis and advanced cardiac stage IIIB disease; patients with inadequate response…
Robotic-assisted conversion of unicompartmental to total knee arthroplasty: a systematic review.
This PRISMA-guided systematic review assessed robotic-assisted conversion of unicompartmental knee arthroplasty (UKA) to total knee arthroplasty (TKA).
Umbrella review of low-level light therapy: evidence across clinical conditions.
This umbrella review synthesized systematic reviews and meta-analyses of low-level light therapy (LLLT) in humans across clinical conditions. It included 100 reviews, covering 790 unique primary studies.
Uniportal versus Multiportal Video-Assisted Thoracoscopic Surgery for Minimally Invasive Esophagectomy in Esophageal Cancer: A GRADE-Assessed Systematic Review and Meta-Analysis.
This GRADE-assessed systematic review and meta-analysis compared uniportal (uVATS) with multiportal video-assisted thoracoscopic surgery (mVATS) for minimally invasive esophagectomy in adults with esophageal cancer.
Association of immune checkpoint-related polymorphisms in PD-1, PD-L1, and CTLA-4 genes with susceptibility to genitourinary cancer: a meta-analysis.
This meta-analysis pooled evidence from 16 case-control studies examining six single-nucleotide polymorphisms in PD-1, PD-L1, and CTLA-4 genes and susceptibility to genitourinary cancers, including urothelial, renal…
Impact of structured sexual health training incorporating standardised patients on health professions students' sexual health communication competence: A single-blind randomised controlled trial in Tanzania.
This single-blind, parallel-group randomised controlled trial evaluated structured sexual health training incorporating standardised patients (SPs) among undergraduate medical and nursing students at a university in…
Acceptability and Feasibility of an Islamic Faith-Based Smoking Cessation Intervention Delivered via WhatsApp for Muslim Smokers in Saudi Arabia: Pilot Randomized Controlled Trial.
This two-arm pilot randomized controlled trial assessed the feasibility, acceptability, and preliminary outcomes of a 21-day Islamic faith-based smoking cessation intervention delivered by WhatsApp to adult Muslim…
Modulation of the gut microbiome and resistome by antibiotic use, but not by subsequent 2'-fucosyllactose intake, in adults with overweight or obesity.
This randomized, double-blind, placebo-controlled intervention examined gut microbiome and resistome changes in 18 adults with overweight or obesity after seven days of vancomycin, followed by eight weeks of…
Epididymal cysts in children: a systematic review and meta-analysis of treatment approaches and clinical outcomes.
This PRISMA-compliant systematic review and meta-analysis synthesised observational evidence on epididymal cysts in boys younger than 18 years.
Quality of recovery after arthroscopic meniscectomy with remimazolam or propofol anesthesia: A randomized controlled trial.
This randomized controlled trial compared propofol-based with remimazolam-based total intravenous anesthesia in adults undergoing elective arthroscopic meniscectomy.
Symptom improvement with dosing above 9 g of low-sodium oxybate: effectiveness and safety in participants with narcolepsy in the DUET study.
This prospective, multicohort, open-label study evaluated effectiveness and safety of low-sodium oxybate (LXB) doses above 9 g/night in participants with narcolepsy type 1 or 2 who were already taking 9 g/night.
Effect of Previsit AI-Generated Document Summaries on Consultation Time and Patient-Physician Communication - The AI-INFOCARE Randomized Controlled Trial.
This single-center randomized controlled trial evaluated whether a quality-checked, AI-generated lay summary of medical findings before outpatient neurosurgical consultations affected communication and consultation…
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