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2000 articles
October 202624
Astrocytic and Axonal Injury Biomarkers in AQP4 Antibody-Positive NMOSD: Insights From PREVENT and CHAMPION-NMOSD.
This biomarker analysis used samples from the phase 3 PREVENT and CHAMPION-NMOSD trials to assess serum GFAP and NfL in people with AQP4 antibody-positive NMOSD receiving eculizumab or ravulizumab.
Effects of Blood Pressure Lowering by Hematoma Location in Acute Intracerebral Hemorrhage.
This pooled individual-patient analysis of five international randomised controlled trials examined whether hematoma location modifies the effect of early intensive blood pressure lowering in acute intracerebral…
Changes in ectopic lipids, insulin sensitivity, and beta cell function after a low-fat vegan diet in adults with type 2 diabetes: a 16-week single-arm clinical trial.
This 16-week, single-arm clinical trial examined changes in ectopic lipids, insulin sensitivity, advanced glycation end products, and beta-cell function in 25 adults with type 2 diabetes following an ad libitum low-fat…
Intracerebral stimulation inducing emotions in SEEG: a systematic review.
This systematic review examined subjective emotional responses to direct intracerebral stimulation during SEEG, synthesizing 34 publications (21 cohort studies and 13 clinical cases) involving 2434 patients and 14,492…
Multimodal MRI markers of white matter hyperintensities and their impact on cognition in cerebral small vessel disease: a systematic review.
This systematic review examined associations between multimodal MRI markers of white matter hyperintensities (WMH) and cognition in adults with cerebral small vessel disease.
A multicenter randomized phase III trial of weekly cisplatin chemoradiotherapy versus radiotherapy in elderly patients with head and neck squamous cell carcinoma unfit for high-dose cisplatin: JCOG2405 (ELDER-WEEKLY).
JCOG2405 (ELDER-WEEKLY) is a planned multicenter, randomized phase III trial comparing radiotherapy plus weekly cisplatin (40 mg/m2) with radiotherapy alone in patients aged ≥70 years with locally advanced head and neck…
Genotype-informed docosahexaenoic acid dosing based on the FADS Indel to reduce preterm and prolonged gestation: A secondary analysis of the ADORE randomized trial.
This post hoc secondary analysis of the multicentre ADORE randomised trial examined whether FADS Indel genotype modified the association between DHA dose and gestational outcomes.
Extensive Aplasia Cutis Congenita with Calvarial Defect and Superior Sagittal Sinus Exposure in a Term Neonate: A Case Report of Successful Healing with Conservative Management.
A term male neonate presented with an approximately 4 × 4 cm midline frontoparietal scalp defect involving the skin and calvarium, with the superior sagittal sinus exposed.
Pancreatic Tuberculosis Mimicking Pancreatic Cancer in a Young Immunocompetent Man: A Case Report and Literature Review.
A 34-year-old HIV-seronegative Afghan man had a year of intermittent epigastric pain, nausea, and vomiting. CT showed a 57×30 mm multiloculated hypoattenuating mass in the pancreatic head without biliary dilation; serum…
Values, preferences, and treatment burden for initiation of GLP-1 receptor agonists, SGLT-2 inhibitors, tirzepatide, and finerenone in adults with type 2 diabetes: systematic review.
This systematic review synthesised quantitative and qualitative evidence on treatment values, preferences, and perceived burden among adults with type 2 diabetes considering GLP-1 receptor agonists, SGLT-2 inhibitors…
Immunohistochemistry for c-MET, HLA class II, and CD68 does not show prognostic value in early-stage classic Hodgkin lymphoma patients in the EORTC-GELA H9 intergroup randomised trial.
This case-cohort biomarker validation study examined whether immunohistochemical expression of c-MET, HLA class II, or CD68 predicted progression-free survival in patients with early-stage classic Hodgkin lymphoma…
A Lynch syndrome patient with multiple cancers who was found to have a novel pathogenic variant generating aberrant splicing of MLH1.
A Japanese woman with colorectal, gastric, and endometrial cancers was found to carry the germline MLH1 variant c.545G>T (p.Arg182Met), initially classified by a clinical testing laboratory as a variant of uncertain…
Bobble-Head Doll Syndrome Caused by Aqueductal Web-Associated Obstructive Hydrocephalus in an Adult: A Case Report with Video.
A 24-year-old man developed progressive memory impairment, gait instability, urinary incontinence, and an irregular side-to-side (“no-no”) head tremor that improved with a sensory trick.
Clinical and Electrophysiological Heterogeneity of Orthostatic Tremor: An Individual Patient Data Analysis.
Orthostatic tremor (OT) is traditionally classified using tremor frequency and the presence of associated neurological signs.
Association Between a Hybrid Video-Guided Multicomponent Exercise Program With Staff Assistance and Free-Living Gait in Older Adults With Knee and Low Back Pain: Secondary Analysis of a Randomized Controlled Trial.
This secondary analysis of a randomized controlled trial examined whether a 12-week hybrid exercise program affected free-living walking in 59 community-dwelling adults aged 65 years or older with mild to moderate knee…
Case Report: Atypical femoral fractures in adult-onset hypophosphatasia treated with low-dose asfotase alfa and adjunctive teriparatide therapy.
A 52-year-old woman presented with progressive pain and bilateral atypical femoral fractures. Low alkaline phosphatase, markedly elevated pyridoxal 5'-phosphate, prior metatarsal fracture, premature tooth loss, and…
Ilioinguinal-Transversus Abdominis Plane (I-TAP) Block with Liposomal Bupivacaine for Analgesia After Cesarean Delivery: A Randomized Controlled Trial.
Cesarean delivery is frequently associated with suboptimal postoperative analgesia. While PROSPECT guidelines recommend transversus abdominis plane (TAP) block for post-cesarean analgesia, conventional TAP block may…
Intravascular imaging guidance in complex PCI: a meta-analysis of randomized trials across complex lesion subsets.
This meta-analysis pooled randomized trials comparing intravascular imaging (IVI)-guided with angiography-guided PCI in patients with trial-defined complex PCI or extractable complex-lesion cohorts.
Effect of Anterior Quadratus Lumborum Block at the Lateral Supra-Arcuate Ligament Combined with Esketamine on the Quality of Postoperative Recovery After Laparoscopic Radical Surgery for Elderly Patients with Colorectal Cancer: A Randomized Controlled Trial.
This single-centre, randomized, placebo-controlled trial evaluated anterior quadratus lumborum block at the lateral supra-arcuate ligament (QLB-LSAL), low-dose esketamine, or their combination in patients aged 60 years…
Perioperative Nursing Care of a Patient With 70% TBSA Second- To Third-Degree Flame Burns Complicated by Pseudomonas aeruginosa Infection: A Case Report.
A patient with 70% TBSA second- to third-degree flame burns developed a Pseudomonas aeruginosa infection and required surgical care, including back debridement.
Optogenetic Therapy for Restoring Aspects of Visual Function.
This open-label clinical trial evaluated safety and visual-function outcomes after ganglion cell-directed optogenetic therapy in 10 participants with blindness from advanced retinitis pigmentosa.
Varicella zoster virus meningitis with a dermatomal rash in immunocompetent hosts: a systematic review and novel case report.
A 44-year-old immunocompetent man presented with fever, severe headache, and a right-sided vesicular rash in the C4-C5 dermatomes. He was initially misdiagnosed with a tick-borne illness.
Comparative effects of inspiratory and expiratory muscle training on diaphragm adaptations and respiratory function in adolescent athletes: a randomized-controlled study.
This randomized controlled study compared inspiratory muscle training (IMT) with expiratory muscle training (EMST) in 26 adolescent female volleyball players.
The relationship between fear of negative evaluation and social anxiety: a systematic review and meta-analysis.
This systematic review and meta-analysis examined the association between fear of negative evaluation (FNE) and social anxiety (SA) across 143 studies and 146 independent samples, including 80,285 participants.
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