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2000 articles
October 202624
Long-term Results of Multiantigen Stimulated Cell Therapy I, Alone or in Combination with Chemotherapy, as First-line Maintenance Therapy in Advanced Sarcoma: A Multicenter, Phase I Trial.
This multicenter, phase I trial evaluated multiantigen stimulated cell therapy I (MASCT-I), alone or with ifosfamide, as first-line maintenance therapy in 31 patients with advanced sarcoma whose disease was controlled…
Modulation of the gut microbiome and resistome by antibiotic use, but not by subsequent 2'-fucosyllactose intake, in adults with overweight or obesity.
This randomized, double-blind, placebo-controlled intervention examined gut microbiome and resistome changes in 18 adults with overweight or obesity after seven days of vancomycin, followed by eight weeks of…
Global Underutilization of Antiviral Therapy and Survival Outcomes in Hepatitis B Virus-Related Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of 78 Studies and 68,243 Patients.
This systematic review and meta-analysis assessed antiviral use and its association with survival and hepatocellular carcinoma (HCC) recurrence in adults with HBV-related HCC.
Efficacy of Stromal Vascular Fraction for Scar Prevention: A Multicenter, Double-Blinded, Randomized Controlled Trial.
This multicenter, double-blinded, placebo-controlled randomized trial evaluated intraoperative stromal vascular fraction (SVF) injections for scar prevention in 45 patients undergoing free tissue transfer at three…
Dynamics of QuantiFERON-TB Gold Plus Results in a Large TB Preventive Treatment Trial Across 3 High-Burden HIV/TB Countries.
This longitudinal analysis of a randomized trial assessed serial QuantiFERON-TB Gold Plus (QFT-Plus) results in people with HIV enrolled in Ethiopia, Mozambique, and South Africa and assigned to three TB preventive…
Uniportal versus Multiportal Video-Assisted Thoracoscopic Surgery for Minimally Invasive Esophagectomy in Esophageal Cancer: A GRADE-Assessed Systematic Review and Meta-Analysis.
This GRADE-assessed systematic review and meta-analysis compared uniportal (uVATS) with multiportal video-assisted thoracoscopic surgery (mVATS) for minimally invasive esophagectomy in adults with esophageal cancer.
Evidence on Glutathione and Boosters for Prevention of Chemotherapy-Induced Neuropathy: A Systematic Review and Network Meta-Analysis.
This systematic review and network meta-analysis compared glutathione (GSH) and GSH boosters for preventing chemotherapy-induced peripheral neuropathy (CIPN), drawing on 25 randomised controlled trials involving 1625…
Phase 2 Trial of Icotrokinra for Patients with Ulcerative Colitis.
This phase 2b, double-blind, randomized trial evaluated once-daily oral icotrokinra, an interleukin-23 receptor blocker, in adults with moderately to severely active ulcerative colitis.
A Prospective, Multicenter, Evaluator-Blind, Randomized, Comparator-Controlled Study of Belotero Intense (+), a Hyaluronic Acid Filler With Lidocaine, for Lip Augmentation.
This multicenter, evaluator-blind randomized comparator-controlled equivalence trial assessed Belotero Intense with lidocaine (BIL) for lip augmentation in patients with lip volume deficits, comparing it with Restylane…
The impact of prophylactic azithromycin on the developing preterm gut microbiome and resistome.
This multicentre, double-blind, randomised, placebo-controlled trial examined the effects of 10 days of prophylactic intravenous azithromycin on the gut microbiome and resistome of 693 preterm infants born before 30…
Immunogenicity of a Bivalent Typhoid-Paratyphoid Conjugate Vaccine Against Diverse Salmonella Paratyphi A Isolates.
This exploratory analysis of a phase 1 randomised controlled trial assessed O:2-specific IgA and IgM responses and serum bactericidal activity after two doses of a bivalent typhoid-paratyphoid conjugate vaccine.
Safety and efficacy of delpacibart zotadirsen in Duchenne muscular dystrophy mutations amenable to exon 44 skipping in the USA (EXPLORE44): a randomised, placebo-controlled, double-blind, phase 1/2 trial.
EXPLORE44 was a two-part, randomised, double-blind, placebo-controlled phase 1/2 trial at ten US sites, studying delpacibart zotadirsen (del-zota) in healthy adult men and in ambulatory and non-ambulatory males aged…
Rilvegostomig for Metastatic Non-Small Cell Lung Cancer: A First-In-Human Phase I/II Clinical Study.
This first-in-human, multicenter, open-label phase I/II study evaluated rilvegostomig, a bispecific antibody targeting PD-1 and TIGIT, in patients with PD-L1-positive advanced or metastatic non-small cell lung cancer…
Optimizing Autologous Fat Grafting: A Systematic Review of Enhancement Strategies and Graft Survival.
This systematic review assessed strategies for enriching autologous fat grafts to improve graft survival, drawing on animal and clinical studies published through February 2025.
Optimization of Anticoagulation Strategy During Cardiopulmonary Bypass in Neonates with Congenital Heart Disease: A Randomized Controlled Trial.
Neonatal hemostatic immaturity complicates anticoagulation during cardiopulmonary bypass (CPB). Current practice largely follows the strategy of 400 U/kg from adult protocols, as neonatal-specific guidelines and…
Intracranial metastasis as a mimic of amyloid-related imaging abnormalities.
A 79-year-old woman with biomarker-confirmed Alzheimer’s disease developed progressive vasogenic edema while receiving lecanemab.
A Systematic Review of Screen Time and Obesity in Children, Adolescents, and Young Adults: Sex-Specific Pathways and Implications for Public Health Interventions.
This systematic review synthesized evidence on screen time and obesity-related outcomes in children, adolescents, and young adults, examining possible sex-specific patterns.
Key Predictors of Cerebral Vasospasm Following Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis examined observational evidence on factors associated with cerebral vasospasm after subarachnoid hemorrhage (SAH).
Artificial intelligence EEG biomarkers for schizophrenia diagnosis: Systematic review with PROBAST+AI assessment.
This systematic review assessed the diagnostic performance and methodological quality of AI models using resting-state EEG to identify schizophrenia or first-episode psychosis.
Immune checkpoint inhibitor-related myocarditis, myositis, and myasthenia gravis overlap syndrome: a single-center case series and systematic review.
The aim of our study was to evaluate the clinical, diagnostic, therapeutic, and prognostic features of immune checkpoint inhibitor-related myocarditis, myositis, and myasthenia gravis overlap syndrome (IM3OS).
PERCUTANEOUS MECHANICAL THROMBECTOMY: A NEW TOOL IN THE TREATMENT OF ACUTE MESENTERIC ISCHEMIA.
An 82-year-old woman with atrioventricular block, hypertension, and dementia presented with acute abdominal pain that had begun three days earlier.
A Meta-Analysis on Outcomes of Zanidatamab Plus Chemotherapy in Patients with Advanced HER2-positive Gastroesophageal Adenocarcinoma.
This meta-analysis pooled outcomes from three clinical trials involving 685 patients with advanced HER2-positive gastroesophageal adenocarcinoma treated first-line with zanidatamab plus chemotherapy, with or without…
Coronary microvascular dysfunction in patients undergoing transcatheter aortic valve implantation: A systematic review and meta-analysis.
This systematic review and meta-analysis examined coronary microvascular dysfunction (CMD) in adults with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI).
The ability of the commercial inertial measurement unit-based gait system in determining Parkinson's disease: A systematic review with meta-analysis of cross-sectional studies.
This systematic review and meta-analysis of cross-sectional studies assessed whether commercial inertial measurement unit (IMU)-based gait systems distinguish people with Parkinson’s disease (PD) from healthy controls.
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