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1999 articles
October 202624
Cutaneous features of SDR9C7 variants in eight individuals with autosomal recessive nonsyndromic epidermal differentiation disorders.
Eight individuals with SDR9C7 variants and nonsyndromic epidermal differentiation disorders had scaling and erythema, commonly with fine scale, hyperlinear palms, and greater involvement of the extremities, particularly…
The role of tyrosine kinase inhibitors as a post-hematopoietic stem cell transplant continuation therapy for pediatric acute leukemia: a systematic review.
This systematic review assessed tyrosine kinase inhibitors (TKIs) as continuation therapy after hematopoietic stem cell transplantation (HSCT) in children with acute leukemia.
Purrble Use Among LGBTQ+ Young People With Self-Harm Experiences: Findings From a Qualitative Process Evaluation of a Randomized Controlled Trial.
This qualitative process evaluation explored how LGBTQ+ young people with self-harm experiences used and perceived Purrble, a socially assistive robot evaluated in a related randomized controlled trial.
Endobronchial Valves for Persistent Air Leak and Bronchopleural Fistula in Children: A Systematic Review of Indications, Procedural Approaches, and Outcomes.
This systematic review examined bronchoscopic endobronchial or intrabronchial valve placement for persistent air leak, bronchopleural fistula, or pneumothorax with ongoing air leak in children and late adolescents.
Comparison of the Safety and Efficacy of Remimazolam for Sedation in Adults Undergoing Fiberoptic Bronchoscopy: A Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis of randomized controlled trials compared remimazolam with other sedatives in adults undergoing fiberoptic bronchoscopy.
Long-term remission of severe psoriasis following CD19-directed chimeric antigen receptor T-cell therapy for follicular lymphoma.
A 60-year-old woman with a 49-year history of severe plaque psoriasis received autologous CD19-directed CAR-T therapy for follicular lymphoma.
Evaluating treatment efficacy for Iliotibial Band Syndrome: A comparison of combined foam rolling and stretching with strengthening exercises versus strengthening alone in athletes.
This randomized controlled trial compared strengthening alone with strengthening plus foam rolling and stretching in 20 athletes with confirmed iliotibial band syndrome.
Cost-effectiveness of recommended interventions for managing low back pain: A systematic review.
This systematic review assessed the cost-effectiveness of guideline-recommended interventions for non-specific low back pain compared with usual care.
Rare and Novel Hepatitis C Virus Genotype Subtypes and Response to Sofosbuvir/Velpatasvir in A5360 (MINMON) Clinical Trial.
This analysis of samples from the multicountry ACTG A5360 (MINMON) clinical trial characterized rare and novel hepatitis C virus (HCV) subtypes and assessed baseline resistance-associated substitutions and response to…
Safety and efficacy of dual immune checkpoint inhibition for melanoma brain metastases and its comparison to ICI monotherapy: A systematic review and meta-analysis.
This PRISMA-based systematic review and meta-analysis pooled prospective and retrospective studies of adults with cutaneous or mucosal melanoma brain metastases treated with dual immune checkpoint inhibition (ICI), and…
Intrauterine Mepivacaine Instillation vs Placebo for Pain During IUD Placement: A Randomized Clinical Trial.
This multicentre, double-blind, randomised, placebo-controlled trial tested intrauterine mepivacaine before IUD placement in nulliparous individuals aged 18 to 31 years at 11 Swedish clinics.
Isolated Disturbance of Consciousness as Initial Presentation of Staphylococcus aureus Endocarditis: A Case Report With Brief Literature Review.
A man in his 50s presented with isolated disturbance of consciousness and no reported fever, although his admission temperature was 38°C.
STRONG prehabilitation before elective ventral hernia repair: Learnings from recruitment challenges in a randomized controlled trial.
The multicentre, parallel-group STRONG-Hernia randomised controlled trial assessed intensive lifestyle prehabilitation before elective ventral hernia repair in adults with at least one risky smoking, nutrition, alcohol…
Efficacy and safety of icotrokinra for plaque psoriasis: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed icotrokinra, an oral IL-23 receptor antagonist, in adolescents and adults with moderate-to-severe plaque psoriasis.
Virtual reality surgical simulator training of residents and early-career surgeons for pedicle screw placement: a systematic review and meta-analysis.
This systematic review and meta-analysis included six randomized controlled trials comparing virtual reality (VR) simulation with conventional teaching for pedicle screw placement training in residents and early-career…
Permissive Blood Pressure Targets in Pediatric Critical Care: The PRESSURE Randomized Clinical Trial.
The multicenter, unblinded pragmatic randomized PRESSURE trial compared a permissive mean arterial pressure (MAP) target (greater than the fifth percentile for age) with usual physician-set targets in hypotensive…
Revascularization in Asymptomatic Carotid Artery Stenosis With Hemodynamic Impairment and Cognitive Outcomes: The CREST-H Substudy of the CREST-2 Randomized Clinical Trial.
This multicenter substudy of a phase 3 randomized clinical trial examined whether baseline cerebral hemodynamic impairment modified cognitive outcomes after carotid revascularization in adults with high-grade…
Evaluating gain and loss-framed mobile messaging to improve maternal health service uptake: A cluster randomized controlled trial in Jimma, Ethiopia.
This three-arm cluster-randomized controlled trial assessed whether gain- or loss-framed SMS messaging improved maternal health service use among 588 pregnant women in Jimma Zone, Ethiopia.
Fertility Treatment and Risk of Melanoma: A Certainty-Rated Systematic Review and Meta-Analysis of 3,733,499 Women.
This certainty-rated systematic review and random-effects meta-analysis examined observational evidence on fertility treatment and incident melanoma in women.
Berberine improves diabetic foot ulcer healing after tibial transverse osteotomy by inhibiting the PDGF-B/PDGFRβ signaling pathway .
This prospective, single-centre, randomized, placebo-controlled trial evaluated local berberine injections added to tibial transverse osteotomy (TTO) in patients with Wagner grade 2–4 diabetic foot ulcers.
Intracardiac thrombus and multiple venous thromboses revealing focal segmental glomerulosclerosis.
A 51-year-old woman presented with two weeks of lower-limb edema and hematuria. Imaging showed lower-extremity deep vein thrombosis, partial left renal vein thrombosis, and a 23 × 20 mm left ventricular thrombus.
Safety of low lipoprotein(a) levels: the FOURIER trial.
This analysis of the randomized, multicentre FOURIER trial examined associations between lipoprotein(a) [Lp(a)] levels and safety outcomes in patients with stable atherosclerotic cardiovascular disease receiving…
Dyspnea Reduction With L-Menthol Inhalation Improves High-Intensity Endurance Running Performance in Healthy Trained Adults.
This randomized, counterbalanced crossover trial tested whether L-menthol inhalation reduces breathlessness and improves high-intensity running performance in 18 trained endurance runners with normal spirometry.
Sialadenopapillary Ductal Tumor: Case Series and Review of the Literature.
The authors describe three patients with sialadenopapillary ductal tumors, a rare neoplasm of likely minor salivary gland origin characterized by prominent submucosal ductal proliferation and multilayered cystic…
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