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2000 articles
October 202624
Staged bilateral MR-guided focused ultrasound thalamotomy in a patient with cerebral cavernous malformations.
A man in his late 60s with medication-refractory essential tremor was found on preoperative MRI to have cavernous malformations in the left caudate head and basal ganglia, with an associated developmental venous anomaly…
Time to improve laboratory protocols in microbial keratitis: broad-range Internal Transcribed Spacer sequencing in refractory culture-negative keratitis.
A woman in her 60s who wore soft contact lenses developed rapidly progressive microbial keratitis that did not respond to intensive empirical treatment.
Emerging risks of health optimisation: refractory nausea associated with peptide injections reported to contain retatrutide.
A woman in her mid-20s presented with five days of persistent nausea, repeated vomiting, loose stools and markedly reduced oral intake.
Meckel's diverticulum leading to axial torsion and volvulus of the small bowel.
A patient presented with small-bowel obstruction caused by a giant Meckel’s diverticulum measuring 22 cm × 11 cm × 9.8 cm. The diverticulum produced mass effect and was associated with axial torsion and volvulus of the…
Effects of remimazolam versus propofol on cerebral oxygenation in elderly patients undergoing prone spine surgery: study protocol for a randomised controlled trial.
This article describes the protocol for a prospective, single-centre randomised controlled trial comparing remimazolam with propofol-based total intravenous anaesthesia in elderly patients undergoing elective thoracic…
Fatal haemophagocytic lymphohistiocytosis and atypical haemolytic uraemic syndrome following coronavirus disease 2019 infection.
A previously healthy woman in her early 30s developed rash, fever and arthralgia three weeks after SARS-CoV-2 infection, followed by rapidly progressive multiorgan failure.
Atypical presentations of Lhermitte's sign after treatment for human papillomavirus-associated oropharyngeal squamous cell carcinoma.
Two patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma developed Lhermitte’s sign after chemoradiotherapy.
Fregoli syndrome in an adolescent with Moyamoya disease.
An early adolescent with known Moyamoya disease developed acute psychosis after a febrile illness accompanied by headache and vomiting.
Idiopathic multicentric Castleman disease in an HIV-positive child.
A preadolescent girl with HIV presented with fever and unilateral facial and neck swelling. Examination showed generalised lymphadenopathy, hepatosplenomegaly, hypertension and haematuria, initially suggesting…
Short- versus long-course antibiotic therapy in non-severe CAP in children: a systematic review and meta-analysis.
This systematic review and meta-analysis compared short-course (≤ 5 days) with longer (> 5 days) antibiotic therapy for non-severe community-acquired pneumonia in immunocompetent children.
Sunitinib in Patients With Various Solid Tumors With FGFR1 / 2 Alterations: Results From the Targeted Agent and Profiling Utilization Registry (TAPUR) Study.
This phase II basket trial evaluated sunitinib in patients with advanced solid tumours and FGFR1 or FGFR2 alterations who had no remaining standard treatment options. Histology-specific cohorts were pooled by alteration.
Skeletal muscle adaptation to home-based exercise in chronic kidney disease.
This randomized controlled trial examined skeletal muscle responses to a 12-week, personalized home-based exercise program in 25 people with stage 3–5 chronic kidney disease (19 assigned to exercise and 6 to usual…
Early interventions for primary care patients with stress-related mental ill health: a randomised controlled non-inferiority trial of a nurse-led collaborative care intervention versus cognitive behavioural therapy.
This randomised controlled non-inferiority trial compared nurse-led collaborative care (CC) with psychologist-guided self-help cognitive behavioural therapy (GSH-CBT) in 172 adults with mild to moderate stress-related…
Manual compared to automated closed-loop oxygen control strategies in hospitalised adults: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed randomised controlled trials comparing closed-loop oxygen control (CLOC) with manual adjustment in hospitalised adults receiving noninvasive oxygen.
Phase 2a Randomized Placebo-Controlled Human Challenge Trial of the Respiratory Syncytial Virus L-Protein Inhibitor S-337395 for Respiratory Syncytial Virus Infection.
This phase 2a, randomized, double-blind, placebo-controlled, single-centre human challenge trial assessed oral S-337395 in healthy adults aged 18–55 years inoculated with RSV-A Memphis 37b.
Effect of preoperative video-based digital educational program on incidence of delirium and length of hospital stay following coronary artery bypass grafting: A randomized controlled trial.
This parallel-group randomized controlled trial evaluated whether adding an 8-minute Arabic video-based educational program to standard preoperative education affected delirium and hospital stay after elective…
Survival outcomes following total intravenous versus volatile anesthesia in esophagogastric cancer surgery: a systematic review and meta-analysis.
This systematic review and meta-analysis compared total intravenous anesthesia (TIVA) with volatile anesthesia in adults undergoing curative surgery for esophageal or gastric cancer.
Anxiety and Depression in Athletes of Different Levels Without Current Injury: A Systematic Review With Meta-Analyses.
This systematic review and random-effects meta-analysis examined anxiety and depression in athletes across competitive levels, including those without current injury.
T-cell-redirecting therapies in early relapsed multiple myeloma: a systematic review and network meta-analysis.
This systematic review and network meta-analysis compared T-cell-redirecting regimens in randomized phase 3 trials involving patients with multiple myeloma after at least one prior line.
Systematic Review and Meta-Analyses of Time-Use, Productivity, and Labor Outcomes Among Unpaid Cancer Caregivers.
This systematic review and meta-analysis pooled evidence on time use and labor outcomes among unpaid caregivers of adults with cancer.
EACTS Expert Consensus Document on aortic valve repair and valve-sparing aortic root replacement procedures.
This EACTS Expert Consensus Document critically reviews evidence on aortic valve repair and valve-sparing aortic root replacement for aortic regurgitation and proximal thoracic aortic aneurysms across age groups.
Managing 7-Hydroxymitragynine Use Disorder with Buprenorphine-Naloxone.
A patient who had used kratom to stop illicit opioids developed tolerance and transitioned to 7-hydroxymitragynine, believing the plant-derived product was safe.
Synbiotic supplementation leads to gut microbiome communities with functional capacity linked to better brain white matter development in preterm infants.
This secondary analysis of a randomized controlled trial examined whether daily synbiotic and nutritional supplementation could shape gut microbiome function in very and extremely preterm infants, and how those…
Neoadjuvant niraparib monotherapy for unresectable, homologous recombination deficiency-positive, high-grade serous ovarian cancer (NANT): a multicentre, single-arm, phase 2 trial.
This multicentre, single-arm phase 2 trial evaluated two cycles of neoadjuvant niraparib monotherapy in treatment-naïve patients with HRD-positive, advanced high-grade serous or endometrioid ovarian cancer considered…
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