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2000 articles
October 202624
Effectiveness of traditional mind-body exercises on fall risk test scores and balance in older adults: A systematic review and meta-analysis.
This systematic review and meta-analysis pooled 31 randomized controlled trials involving 3,622 older adults to assess traditional mind-body exercises and fall-risk test scores and balance.
Bone phenotype of patients with genetic forms of lipodystrophy: a systematic review of literature.
This systematic review examined bone manifestations in people with genetic lipodystrophies, using human studies identified through searches of PubMed, EMBASE, and the Cochrane Library.
Acute colonic variceal bleeding treated with coil-assisted retrograde transvenous obliteration following atezolizumab-bevacizumab therapy for advanced hepatocellular carcinoma: A case report.
A 66-year-old man with alcohol-related cirrhosis and advanced hepatocellular carcinoma developed hematochezia the day after starting atezolizumab plus bevacizumab.
Psychological Stress and the Diurnal Patterns of Sodium Excretion and Blood Pressure: Results From the SABRE Study.
The SABRE study examined whether urinary sodium responses to mental stress were associated with day–night sodium excretion patterns and systolic blood pressure (BP) dipping in apparently healthy adults.
Recruitment, Engagement, Experiences, and Self-Reported Changes in a Digital Patient Activation Intervention to Improve Hemodialysis Session Stability: Mixed Methods Study.
This mixed methods study evaluated recruitment, engagement, completion, and participant experiences in Dialysafe, a digital education and peer-mentoring intervention at 10 hemodialysis centers.
Participant Characteristics Associated With Loneliness Reduction During a Digital Social Robot Intervention Among Older Adults Living Alone in Japan: Secondary Analysis of a Randomized Controlled Trial.
This secondary analysis of a randomized controlled trial examined whether participant characteristics were associated with changes in loneliness during a digital social robot intervention among community-dwelling older…
Presumed oxaliplatin-related Guillain-Barré syndrome: A case report and review of chemotherapy-related Guillain-Barré syndrome.
A 77-year-old woman with metastatic cholangiocarcinoma and colorectal carcinoma developed rapidly progressive, symmetric ascending motor weakness about 2 weeks after her last cycle of gemcitabine, oxaliplatin…
Preoperative ureteral rest and outcomes of robot-assisted upper urinary tract reconstruction: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed whether preoperative ureteral rest is associated with outcomes after robot-assisted ureteral reconstruction or pyeloplasty.
Iptacopan combined with immunosuppressive therapy for aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome: A case report.
A previously healthy 24-year-old man presented with dizziness, fatigue, and pancytopenia. Bone marrow examination supported aplastic anemia, with a PNH clone also identified.
Three traditional Chinese patent medicines combined with transarterial chemoembolization for primary liver cancer: A systematic review and Bayesian network meta-analysis.
This systematic review and Bayesian network meta-analysis assessed three traditional Chinese patent medicines combined with transarterial chemoembolization (TACE) for primary liver cancer.
Feasibility and Activity of Concurrent Neoadjuvant Chemotherapy and Radiotherapy in Patients with High-risk Soft-Tissue Sarcoma.
This analysis of the international, randomized phase III ISG-STS 1001 trial assessed concurrent epirubicin–ifosfamide chemotherapy (EI) and radiotherapy in patients with localized, high-risk soft-tissue sarcoma.
Multicenter Phase I Study of Triapine in Combination with [177Lu]Lutetium-Dotatate in Patients with Well-Differentiated Neuroendocrine Tumors (ETCTN 10388).
This multicenter phase I dose-escalation and dose-expansion study evaluated [177Lu]lutetium-dotatate plus oral triapine in patients with well-differentiated gastroenteropancreatic neuroendocrine tumors.
Comparative Efficacy and Safety of Systemic Immunomodulatory Therapies for Non-Infectious Uveitis: A Systematic Review With Pairwise and Network Meta-Analyses.
This systematic review and network meta-analysis compared systemic immunomodulatory therapies for non-infectious uveitis (NIU), including evidence from seven studies with 992 participants: six randomised trials and one…
Circulating Thymidine Kinase Activity Predicts Survival and Optimal Treatment Sequencing in BRAF-Mutated Metastatic Melanoma in the SECOMBIT Trial.
This randomized phase II trial biomarker analysis evaluated circulating thymidine kinase activity (TKa) in patients with BRAF V600-mutated metastatic melanoma receiving targeted therapy (TT), immune checkpoint…
Phase I Trial of IL13Rα2-Targeted CAR T-cell Therapy for Recurrent Malignant Glioma: Clinical Results and Pharmacokinetics.
This single-centre, open-label phase I trial assessed intravenous autologous IL13Rα2-targeted CAR T cells in adults with recurrent, IL13Rα2-expressing grade 3–4 gliomas after standard treatment.
Efficacy and Safety of Necitumumab and Pembrolizumab Combination Therapy in Advanced Non-Small Cell Lung Cancer with ≥50% PD-L1 Expression: A Nonrandomized Phase II Trial.
This nonrandomized, multicenter, open-label, single-arm phase II trial evaluated first-line pembrolizumab plus necitumumab in 50 patients with previously untreated advanced NSCLC and PD-L1 tumor proportion score ≥50%.
FDA Approval Summary: Retifanlimab for the Treatment of Adult Patients with Metastatic or Inoperable Locally Recurrent Squamous Cell Carcinoma of the Anal Canal.
This FDA approval summary describes evidence from POD1UM-303, a randomised trial in 308 patients with advanced squamous cell carcinoma of the anal canal (SCAC) and no prior systemic treatment for advanced disease, and…
Blood-based biomarkers in patients with recurrent, persistent, or metastatic endometrial cancer treated with olaparib and cediranib: Results from NRG-GY012.
This biomarker analysis of the phase 2 NRG-GY012 clinical trial assessed blood-based markers and outcomes among patients with recurrent, persistent, or metastatic endometrial cancer treated with olaparib, cediranib, or…
Efficacy and safety of baxdrostat in the management of uncontrolled hypertension: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed baxdrostat versus placebo in randomized controlled trials involving patients with uncontrolled hypertension.
Immunogenicity of a Bivalent Typhoid-Paratyphoid Conjugate Vaccine Against Diverse Salmonella Paratyphi A Isolates.
This exploratory analysis of a phase 1 randomised controlled trial assessed O:2-specific IgA and IgM responses and serum bactericidal activity after two doses of a bivalent typhoid-paratyphoid conjugate vaccine.
Geographic Variation in Diagnostic Performance of Amsel Criteria and Nugent Score for Vaginal Dysbiosis Defined by 16S rRNA Gene Sequencing.
This analysis compared Amsel criteria and Nugent scoring with 16S rRNA sequencing-defined vaginal community state types in screening and follow-up specimens from a Phase 1b randomized trial at sites in South Africa and…
Primary Hepatic Neuroendocrine Neoplasms: Systematic Review and Expert Pathologist Reappraisal Using the WHO 6th Edition Framework.
Primary hepatic neuroendocrine neoplasms (PHNENs) are exceedingly rare. Published evidence often lacks adequate clinicopathological support for a primary hepatic origin and uses inconsistent historical terminology.
Epididymal cysts in children: a systematic review and meta-analysis of treatment approaches and clinical outcomes.
This PRISMA-compliant systematic review and meta-analysis synthesised observational evidence on epididymal cysts in boys younger than 18 years.
Intracranial metastasis as a mimic of amyloid-related imaging abnormalities.
A 79-year-old woman with biomarker-confirmed Alzheimer’s disease developed progressive vasogenic edema while receiving lecanemab.
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