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2000 articles
October 202624
Regression of uremic tumoral calcinosis following the switch from cinacalcet to etelcalcetide in a hemodialysis patient without severe hyperphosphatemia.
A 46-year-old man receiving maintenance hemodialysis developed progressive peri-articular soft-tissue calcifications that became tumoral calcinosis (TC), involving both thighs and the left elbow and causing a left…
Detection of MOG-IgG and MOG-IgA in Maternal Breast Milk and Infant Blood in MOGAD: A Case Report.
A mother with MOG antibody-associated disease had persistently elevated plasma MOG-IgG, with a transient decrease in early pregnancy.
Astrocytic and Axonal Injury Biomarkers in AQP4 Antibody-Positive NMOSD: Insights From PREVENT and CHAMPION-NMOSD.
This biomarker analysis used samples from the phase 3 PREVENT and CHAMPION-NMOSD trials to assess serum GFAP and NfL in people with AQP4 antibody-positive NMOSD receiving eculizumab or ravulizumab.
Effects of Blood Pressure Lowering by Hematoma Location in Acute Intracerebral Hemorrhage.
This pooled individual-patient analysis of five international randomised controlled trials examined whether hematoma location modifies the effect of early intensive blood pressure lowering in acute intracerebral…
Changes in ectopic lipids, insulin sensitivity, and beta cell function after a low-fat vegan diet in adults with type 2 diabetes: a 16-week single-arm clinical trial.
This 16-week, single-arm clinical trial examined changes in ectopic lipids, insulin sensitivity, advanced glycation end products, and beta-cell function in 25 adults with type 2 diabetes following an ad libitum low-fat…
Accidental Bottle Cap Ingestion in an Adult in a Resource-Limited Setting: A Case Report.
A 53-year-old man presented after accidentally swallowing a bottle top while opening a pressurized reused beverage bottle with his teeth. He had drooling, dysphagia, throat pain, and a foreign-body sensation.
Values, preferences, and treatment burden for initiation of GLP-1 receptor agonists, SGLT-2 inhibitors, tirzepatide, and finerenone in adults with type 2 diabetes: systematic review.
This systematic review synthesised quantitative and qualitative evidence on treatment values, preferences, and perceived burden among adults with type 2 diabetes considering GLP-1 receptor agonists, SGLT-2 inhibitors…
Genotype-informed docosahexaenoic acid dosing based on the FADS Indel to reduce preterm and prolonged gestation: A secondary analysis of the ADORE randomized trial.
This post hoc secondary analysis of the multicentre ADORE randomised trial examined whether FADS Indel genotype modified the association between DHA dose and gestational outcomes.
Advanced Rheumatic Heart Disease Complicated by Pregnancy, Mitral Valve Disease, Pulmonary Hypertension, and Left Atrial Thrombus: A Multidisciplinary Case Report from Resource-Limited Settings.
A 27-year-old woman in late pregnancy presented with progressive dyspnea, palpitations, leg swelling, cough, and fatigue. Echocardiography showed an enlarged left atrium, moderate mitral stenosis with mild regurgitation…
Pancreatic Tuberculosis Mimicking Pancreatic Cancer in a Young Immunocompetent Man: A Case Report and Literature Review.
A 34-year-old HIV-seronegative Afghan man had a year of intermittent epigastric pain, nausea, and vomiting. CT showed a 57×30 mm multiloculated hypoattenuating mass in the pancreatic head without biliary dilation; serum…
Efficacy of technology-based psychosocial interventions on quality of life and psychological outcomes in adolescent and young adult survivors of childhood cancer: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis pooled randomized controlled trials of technology-based psychosocial interventions for adolescent and young adult survivors of childhood cancer.
Case Report: Atypical femoral fractures in adult-onset hypophosphatasia treated with low-dose asfotase alfa and adjunctive teriparatide therapy.
A 52-year-old woman presented with progressive pain and bilateral atypical femoral fractures. Low alkaline phosphatase, markedly elevated pyridoxal 5'-phosphate, prior metatarsal fracture, premature tooth loss, and…
Association between complement de-escalation and prognosis in sepsis: A systematic review and meta-analysis.
This systematic review and meta-analysis examined whether reduced complement activation after treatment was associated with prognosis in patients with sepsis. Eleven studies were included.
Real-World Effectiveness of AI-Enabled Clinical Decision Support in Primary Care: Systematic Review.
This systematic review synthesized real-world evaluations of clinician-facing AI-enabled clinical decision support in primary and ambulatory care, covering studies published from 2011 through 2025.
Prevalence of mental health outcomes among trans and gender diverse adults: a global systematic review and meta-analysis.
This global systematic review and meta-analysis pooled mental health outcome estimates among trans and gender diverse adults. It included 207 studies with 134,071 participants across 52 countries.
Association Between a Hybrid Video-Guided Multicomponent Exercise Program With Staff Assistance and Free-Living Gait in Older Adults With Knee and Low Back Pain: Secondary Analysis of a Randomized Controlled Trial.
This secondary analysis of a randomized controlled trial examined whether a 12-week hybrid exercise program affected free-living walking in 59 community-dwelling adults aged 65 years or older with mild to moderate knee…
Extensive Aplasia Cutis Congenita with Calvarial Defect and Superior Sagittal Sinus Exposure in a Term Neonate: A Case Report of Successful Healing with Conservative Management.
A term male neonate presented with an approximately 4 × 4 cm midline frontoparietal scalp defect involving the skin and calvarium, with the superior sagittal sinus exposed.
Optogenetic Therapy for Restoring Aspects of Visual Function.
This open-label clinical trial evaluated safety and visual-function outcomes after ganglion cell-directed optogenetic therapy in 10 participants with blindness from advanced retinitis pigmentosa.
Contrasting clinical trajectories in two ALS patients with rare FUS variants: implications for variant interpretation, penetrance, and trial readiness.
The report describes two patients with amyotrophic lateral sclerosis (ALS) carrying rare FUS variants. Their clinical courses differed, despite the association of FUS-related ALS with relatively aggressive disease.
Comparative effects of inspiratory and expiratory muscle training on diaphragm adaptations and respiratory function in adolescent athletes: a randomized-controlled study.
This randomized controlled study compared inspiratory muscle training (IMT) with expiratory muscle training (EMST) in 26 adolescent female volleyball players.
Bobble-Head Doll Syndrome Caused by Aqueductal Web-Associated Obstructive Hydrocephalus in an Adult: A Case Report with Video.
A 24-year-old man developed progressive memory impairment, gait instability, urinary incontinence, and an irregular side-to-side (“no-no”) head tremor that improved with a sensory trick.
Adverse childhood experiences, cognitive outcomes, and frailty in older adults: a systematic review and meta-analysis.
This systematic review and meta-analysis examined associations between adverse childhood experiences (ACEs) and frailty or cognitive outcomes in middle-aged and older adults.
Clinical and Electrophysiological Heterogeneity of Orthostatic Tremor: An Individual Patient Data Analysis.
Orthostatic tremor (OT) is traditionally classified using tremor frequency and the presence of associated neurological signs.
Effect of Anterior Quadratus Lumborum Block at the Lateral Supra-Arcuate Ligament Combined with Esketamine on the Quality of Postoperative Recovery After Laparoscopic Radical Surgery for Elderly Patients with Colorectal Cancer: A Randomized Controlled Trial.
This single-centre, randomized, placebo-controlled trial evaluated anterior quadratus lumborum block at the lateral supra-arcuate ligament (QLB-LSAL), low-dose esketamine, or their combination in patients aged 60 years…
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