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2000 articles

October 202624

Clinical ResearchUrologyOpen access

Novel Imaging Techniques Prior to Surgical Management of Invasive Bladder Cancer: A Systematic Review.

This PRISMA-guided systematic review assessed novel imaging for detecting muscle invasion and nodal disease before surgical management of invasive bladder cancer. It included 33 studies encompassing 4,689 patients.

Curr Urol RepOct 22, 2026Read summary
Case ReportOphthalmologyOpen access

Use of the 590-nm CAPSULaser in true open-sky penetrating keratoplasty triple procedures: a technical report of two cases.

Two eyes with advanced corneal opacity and visually significant cataract underwent combined penetrating keratoplasty, cataract extraction, and intraocular lens implantation.

Int OphthalmolOct 21, 2026Read case
Clinical ResearchGastroenterology

Effects of Aerobic Exercise on Autonomic and Endothelial Function and Splanchnic Hemodynamics in Compensated Cirrhosis: RCT Study.

This parallel-group randomised controlled trial assessed 16 weeks of moderate-intensity aerobic exercise plus nutritional consultation versus nutritional consultation alone in 50 sedentary patients with compensated…

Liver IntOct 21, 2026Read summary
Clinical ResearchEndocrinology

Baseline Serum Metabolites as Predictors of Teplizumab Response in Individuals With Type 1 Diabetes.

This analysis examined whether baseline serum metabolites could predict response to teplizumab in 41 people newly diagnosed with type 1 diabetes who participated in the randomized AbATE trial.

DiabetesOct 21, 2026Read summary
Case ReportDermatologyOpen access

Inherited epidermal differentiation disorders (EDD) in pediatric patients from a single Italian referral Center.

A retrospective review at an Italian referral center described three children with congenital, clinically heterogeneous inherited epidermal differentiation disorders.

Eur J PediatrOct 21, 2026Read case
Clinical ResearchPreventive Medicine / Public HealthOpen access

Evaluating a multi-vaccine respiratory immunization strategy involving SARS-CoV-2, pneumococcal, and influenza vaccines in adults: A randomized, open-label, multicenter, controlled, non-inferiority Phase IV trial in China.

This randomized, open-label, multicenter Phase IV trial in China assessed immunogenicity and safety when adults aged ≥18 years received an inactivated SARS-CoV-2 vaccine with PPV23 and IIV4, compared with separate…

Hum Vaccin ImmunotherOct 21, 2026Read summary
Clinical ResearchHematology

The role of allogeneic hematopoietic stem cell transplantation in adults with mature T-cell lymphomas.

This Cochrane systematic review and meta-analysis assessed allogeneic stem cell transplantation (alloSCT) for adults with mature T-cell lymphomas (MTCL), as first-line or salvage treatment.

Cochrane Database Syst RevOct 21, 2026Read summary
Clinical ResearchObstetrics & Gynecology

Endometrial ablation plus levonorgestrel-releasing intrauterine system versus endometrial ablation alone in women with heavy menstrual bleeding in The Netherlands (MIRA2): a multicentre, open-label, randomised, controlled, superiority trial.

MIRA2 was a multicentre, open-label, randomised controlled superiority trial in women younger than 60 years with heavy menstrual bleeding eligible for endometrial ablation.

LancetOct 21, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Feasibility and safety of an exercise-based prehabilitation intervention before cancer surgery: a pilot randomised controlled trial.

This single-centre pilot randomised controlled trial assessed the feasibility and safety of supervised aerobic prehabilitation before surgery in patients with breast, colorectal, or prostate cancer.

Support Care CancerOct 21, 2026Read summary
Clinical ResearchPediatricsOpen access

Parent-child discrepancies in health-related quality of life in pediatric celiac disease: a systematic review and meta-analysis.

This systematic review and meta-analysis examined child–parent differences in health-related quality of life (HRQoL) among children and adolescents with celiac disease, using the disease-specific CDDUX questionnaire.

Eur J PediatrOct 21, 2026Read summary
Clinical ResearchOphthalmology

ULTRAWIDE-FIELD COLOR FUNDUS IMAGES AND ARTIFICIAL INTELLIGENCE FOR DIAGNOSIS OF DIABETIC RETINOPATHY: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis assessed artificial intelligence (AI) for diabetic retinopathy (DR) evaluation using ultrawide-field fundus images.

RetinaOct 21, 2026Read summary
Clinical ResearchInfectious DiseasesOpen access

Sevuparin in children with severe malaria: a phase I safety and dose-finding trial.

This phase I dose-finding trial assessed sevuparin safety and tolerability in Kenyan and Zambian children with severe malaria.

Nat CommunOct 21, 2026Read summary
Clinical ResearchPsychiatry

Semaglutide modulates explore/exploit decision-making in major depressive disorder: A randomized clinical trial.

This secondary analysis of a randomized clinical trial examined whether semaglutide affected explore/exploit decision-making in 72 participants with major depressive disorder (MDD).

Psychol MedOct 21, 2026Read summary
Clinical ResearchNeurologyOpen access

Real-world safety and efficacy of lecanemab in the treatment of Alzheimer's disease: a systematic review and meta-analysis.

This systematic review and meta-analysis pooled real-world studies of lecanemab treatment in people with Alzheimer’s disease, including 37 studies.

J NeurolOct 21, 2026Read summary
Clinical ResearchEndocrinology

From Alert to Action: Electronic Practice Advisory Improves DSMES Referrals Over 18 Months.

This cluster-randomized controlled trial in primary care practices in central North Carolina tested whether an electronic health record best practice advisory (BPA) increased referrals to diabetes self-management…

Diabetes CareOct 21, 2026Read summary
Clinical ResearchRheumatologyOpen access

Association between rheumatic diseases and glaucoma risk: a systematic review and meta-analysis of 5.7 million individuals.

This systematic review and meta-analysis examined glaucoma occurrence and risk among people with rheumatic diseases (RD), drawing on 18 studies with 5,766,143 participants.

Int OphthalmolOct 21, 2026Read summary
Case ReportNeurosurgery

Ultra high-density, 4096-channel intraoperative neurophysiological brain mapping for functional localization of the human central sulcus.

During resection of a right parafalcine meningioma in a 56-year-old man, four flexible 1024-electrode micro-ECoG arrays were used to record somatosensory evoked potentials from the peri-Rolandic cortex during…

J Neural EngOct 21, 2026Read case
Clinical ResearchObstetrics & GynecologyOpen access

The effects of perinatal depression and anxiety on memory, attention, and cognitive flexibility: a systematic review and meta-analysis.

This systematic review and meta-analysis examined whether perinatal depressive and anxiety symptoms are associated with memory, attention, and cognitive flexibility.

Arch Womens Ment HealthOct 21, 2026Read summary
Clinical ResearchOncology (Medical)

Disease-free survival and overall survival after neoadjuvant immunotherapy in mismatch repair-deficient colon cancer in the Netherlands: results of the single-arm, multicentre, phase 2, NICHE-2 trial.

This single-arm, multicentre phase 2 trial assessed neoadjuvant ipilimumab plus nivolumab followed by surgery in previously untreated patients with resectable stage 2 or 3 mismatch repair-deficient colon cancer.

LancetOct 21, 2026Read summary
Clinical ResearchEmergency Medicine

A multifaceted intervention to increase bystander CPR rates after out-of-hospital cardiac arrest in France: a stepped-wedge, cluster-randomised, controlled trial.

This stepped-wedge, cluster-randomised controlled trial assessed a coordinated intervention to increase bystander CPR before EMS arrival among adults with non-traumatic out-of-hospital cardiac arrest in France.

Lancet Public HealthOct 21, 2026Read summary
Clinical ResearchGeriatricsOpen access

Thermographic outcomes of auricular laser acupuncture and auricular seed acupressure in older adults with chronic shoulder pain: an exploratory nonrandomized, nonconcurrent comparison.

This exploratory, open-label, nonrandomized comparison studied 20 adults aged 60–90 years with chronic shoulder pain, allocated by order of entry to auricular laser acupuncture or seed acupressure.

Lasers Med SciOct 21, 2026Read summary
Case ReportCardiology

Spiked Helmet Sign in the Early Post-Heart Transplantation Period: A Dramatic STEMI Mimic in a Structurally Normal Donor Heart.

A 36-year-old woman with severe dilated cardiomyopathy underwent heart transplantation and subsequently developed subarachnoid hemorrhage and septic shock.

Ann Noninvasive ElectrocardiolOct 21, 2026Read case
Clinical ResearchPediatrics

Ruxolitinib for the treatment of pediatric acute and chronic steroid-refractory graft-versus-host disease: Efficacy, safety, and outcomes.

This single-center retrospective study assessed ruxolitinib in children under 18 years with steroid-refractory graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.

Hematol Oncol Stem Cell TherOct 21, 2026Read summary
Clinical ResearchGeriatricsOpen access

Feasibility of a multidimensional interdisciplinary rehabilitation program for people with dementia and their informal primary caregivers - a randomized pilot trial with a caregiver focus.

This randomized pilot trial assessed the feasibility of a person-centred, interdisciplinary rehabilitation program for community-dwelling people with dementia that also provided education and support to informal…

BMC GeriatrOct 21, 2026Read summary

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