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2000 articles

October 202624

Clinical ResearchNeurologyOpen access

The effect of seizure-free period on seizure recurrence following antiseizure medication withdrawal: a systematic review and meta-analysis.

This systematic review and random-effects meta-analysis examined whether the duration of seizure freedom before antiseizure medication (ASM) withdrawal is associated with subsequent seizure recurrence in people with…

J NeurolOct 20, 2026Read summary
Clinical ResearchGeneral SurgeryOpen access

Comparative perioperative and oncological outcomes of the da Vinci Xi versus Si robotic surgical systems in rectal cancer surgery: a systematic review and meta-analysis.

This systematic review and meta-analysis compared perioperative and oncological outcomes with da Vinci Xi versus Si systems in rectal cancer surgery.

J Robot SurgOct 20, 2026Read summary
Clinical ResearchGeriatricsOpen access

Optimizing exercise prescriptions for older adults with mild cognitive impairment: a dose-response network meta-analysis of modality-dose combinations on executive function.

This Bayesian dose-response network meta-analysis synthesized randomized controlled trials of repeated exercise programmes in adults aged 60 years or older with mild cognitive impairment.

PeerJOct 20, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Neoadjuvant Therapy for Gastric Adenocarcinoma with Signet Ring Cells: A Systematic Review and Meta-Analysis.

This systematic review and random-effects meta-analysis assessed neoadjuvant chemotherapy followed by surgery versus upfront gastrectomy in adults with signet ring cell-containing gastric cancer.

J Gastrointest CancerOct 20, 2026Read summary
Clinical ResearchPediatricsOpen access

Oxygen vs Air at Birth for Moderate- to Late-Preterm Infants: The AIROPLANE Cluster Randomized Crossover Trial.

The AIROPLANE trial was an unblinded, cluster randomized crossover study at 26 Australian maternity hospitals comparing initial oxygen concentrations of 0.30 and 0.21 during the first 3 minutes of respiratory support…

JAMAOct 20, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Combination of oral fluoropyrimidines and EGFR-directed antibodies in frail patients with metastatic colorectal cancer: a systematic review.

This systematic review assessed phase II and III evidence for oral fluoropyrimidines combined with EGFR-directed antibodies in patients with RAS wild-type metastatic colorectal cancer, including those considered unfit…

J Cancer Res Clin OncolOct 20, 2026Read summary
Clinical ResearchPsychiatryOpen access

Effectiveness and Influencing Factors of Drama-Based Interventions for Social Skills in Children and Adolescents with Autism Spectrum Disorder: A Meta-Analysis.

This meta-analysis assessed drama-based interventions for social skills in children and adolescents with autism spectrum disorder (ASD), drawing on 16 controlled studies involving 703 participants.

Res Child Adolesc PsychopatholOct 20, 2026Read summary
Case ReportOtolaryngology (ENT)

Cochlear Implantation in a Child With Arnold-Chiari Syndrome, Severe Inner Ear Malformations, and Cochlear Nerve Hypoplasia: A Case Report.

A 1.5-year-old girl with Arnold-Chiari malformation, hydrocephalus, spina bifida, and profound bilateral sensorineural hearing loss had limited auditory development despite early hearing-aid use.

Am J Case RepOct 20, 2026Read case
Clinical ResearchPediatricsOpen access

Ciliated hepatic foregut cyst in children and adolescents: a systematic review of clinical presentation, diagnosis, management, and outcomes.

This PRISMA 2020 systematic review descriptively synthesised case reports and case series of histopathologically confirmed ciliated hepatic foregut cysts in patients aged 19 years or younger.

Pediatr Surg IntOct 20, 2026Read summary
Clinical ResearchInfectious DiseasesOpen access

Initial HIV Therapy for Adults and Treatment-Associated Weight Gain: The Opti-DOR Randomized Clinical Trial.

The Opti-DOR open-label, noninferiority randomized trial compared two initial antiretroviral regimens in 600 ART-naive adults at two South African sites; 99.5% of participants were Black African.

JAMAOct 20, 2026Read summary
Clinical ResearchPediatricsOpen access

Neonatal gastric perforation: a systematic review and meta-analysis of clinical characteristics, risk factors, surgical management and outcomes.

This systematic review and meta-analysis examined clinical features, risk factors, surgical management and outcomes of neonatal gastric perforation using observational studies of neonates aged 28 days or younger.

Pediatr Surg IntOct 20, 2026Read summary
Clinical ResearchNeurosurgeryOpen access

Neurosurgical manifestations and management of mucopolysaccharidoses: A systematic review.

This PRISMA-guided systematic review synthesized contemporary reports of neurosurgical manifestations and management across mucopolysaccharidosis (MPS) subtypes.

Neurosurg RevOct 20, 2026Read summary
Clinical ResearchPediatricsOpen access

Levetiracetam versus valproate for new-onset or previously treated but inadequately controlled epilepsy in children: a systematic review and meta-analysis of randomized controlled trials.

This systematic review and meta-analysis compared levetiracetam with valproate in children aged 0–18 years with new-onset or inadequately controlled epilepsy.

Eur J Clin PharmacolOct 20, 2026Read summary
Clinical ResearchOncology (Medical)

Meta-analysis of 990 EBV genomes identifies EBER2 SNP7048 and its interaction with HLA-A*11:01 driving nasopharyngeal carcinoma risk.

This meta-analysis examined whether EBV genetic variation and host genetics are associated with nasopharyngeal carcinoma (NPC) across endemic populations in Singapore, Hong Kong, and China’s Guangdong and Guangxi…

Proc Natl Acad Sci U S AOct 20, 2026Read summary
Clinical ResearchGeriatrics

Effects of Different Exercise Modalities on Interleukin-6, Brain-Derived Neurotrophic Factor, and Cognitive Function in Obese Older Women.

This randomized controlled trial compared control, aquatic aerobic exercise, aerobic dance, and combined aerobic and resistance exercise in obese women aged 65 years or older.

J Obes Metab SyndrOct 20, 2026Read summary
Clinical ResearchNeurology

Daily consumption of unsalted, skin-roasted peanuts beneficially affects regional brain insulin responsiveness in older adults: results of a longer-term randomized controlled trial.

This randomized, single-blind, controlled crossover trial examined whether peanut intake altered brain insulin responsiveness in 31 older adults (67 ± 4 years).

Food FunctOct 19, 2026Read summary
Case ReportInfectious DiseasesOpen access

Clinical Recovery Following Conservative Management of a Large Presumed Brain Abscess with a Concomitant Streptococcus intermedius Lung Abscess in a Severely Malnourished Young Adult in a Resource-Limited Setting: A Case Report.

A severely malnourished 22-year-old man presented with progressive left-sided weakness after weeks of productive cough, fever, and weight loss. Examination showed impaired consciousness and flaccid hemiplegia.

Int Med Case Rep JOct 19, 2026Read case
Clinical ResearchPhysical Medicine & Rehabilitation

Effectiveness of physical, psychological, and alternative interventions for post-COVID-19 condition: a systematic review.

This systematic review of randomized controlled trials assessed supervised, face-to-face non-pharmacological interventions in adults with WHO-defined post-COVID-19 condition.

J Rehabil MedOct 19, 2026Read summary
Case ReportOncology (Medical)Open access

Conventional Skull Base Chordoma in a Ugandan Adult Male, Presenting with Prolonged Headache: A Case Report.

A 49-year-old man had more than a year of intermittent, progressively worsening headache and reported an episode of facial numbness, although facial sensation and the remainder of his neurological examination were…

Int Med Case Rep JOct 19, 2026Read case
Case ReportNeurologyOpen access

Cerebrospinal fluid positive for SARS-CoV-2 associated with neurological manifestations and proteome alterations in a multiple myeloma patient.

A 67-year-old woman with multiple myeloma and recent exposure to a person with COVID-19 developed rapidly progressive dysarthria, dysphagia, and hypoesthesia without respiratory symptoms.

Neurol SciOct 19, 2026Read case
Clinical ResearchPreventive Medicine / Public Health

Evidence on information, access frictions, and experience in public healthcare use in rural Bangladesh: a cluster-randomized field experiment.

This cluster-randomized field experiment tested whether information, access frictions, or uncertainty about public care helps explain reliance on private and informal providers among rural Bangladeshi households.

Health Policy PlanOct 19, 2026Read summary
Clinical ResearchInfectious Diseases

A process evaluation of community-led distribution of HIV self-testing kits in rural communities in Zimbabwe.

This process evaluation examined community-led HIV self-testing (HIVST) distribution in rural Zimbabwe, within the community-led arm of a cluster-randomized trial comparing it with paid, community-based distribution.

Health Policy PlanOct 19, 2026Read summary
Clinical ResearchGastroenterology

Effects of the GnRH agonist leuprorelin on liver volume in premenopausal women with severe polycystic liver disease.

This prospective, open-label randomized trial evaluated leuprorelin in premenopausal women aged 18–45 years with severe polycystic liver disease (PLD).

Hepatol CommunOct 19, 2026Read summary
Clinical ResearchPsychiatry

The effectiveness of meaning-based interventions in reducing suicide-related vulnerability: A systematic review.

This systematic review examined whether meaning-based interventions affect suicide-related outcomes and how their effects may operate.

Palliat Support CareOct 19, 2026Read summary

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