Trending archive
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1502 articles
October 202624
Impact of Evolocumab on LDL-Cholesterol and Cardiovascular Outcomes in Patients With Established CVD: Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled randomised controlled trials of evolocumab in adults with established cardiovascular disease.
Exploring the Neural Mechanisms of Acupuncture Stimulation in Autism Spectrum Disorder: Protocol for a Randomized, Sham-Controlled, Multimodal Neuroimaging Trial.
This protocol describes a randomized, sham-controlled, stratified 2×2 trial designed to examine brain differences associated with autism spectrum disorder (ASD) and the acute neural response to acupuncture.
Impact of HIF-prolyl hydroxylase inhibitors on VEGF expression and vascular adverse events in chronic kidney disease: a meta-analysis of 34 randomized controlled trials.
This meta-analysis of 34 randomized controlled trials assessed VEGF levels and VEGF-related adverse outcomes with hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) in people with chronic kidney disease.
Effects of gliflozins on bone health of patients with chronic kidney disease: a systematic review.
This systematic review assessed skeletal safety and bone-related metabolic outcomes with sodium-glucose co-transporter-2 inhibitors (SGLT2i) in people with chronic kidney disease, drawing on randomised trials and…
Inhibin B as a biomarker for ovarian reserve and ovarian response: systematic reviews and meta-analyses of diagnostic test accuracy.
This systematic review and meta-analysis assessed the diagnostic accuracy of inhibin B compared with anti-Müllerian hormone (AMH) for ovarian reserve and ovarian response.
Effect of web-based education on NIV-related side effects and insomnia severity in COPD patients using home NIV: a randomized controlled trial.
This randomized controlled trial evaluated web-based education about NIV-related side effects and insomnia management in 75 patients with COPD using home noninvasive ventilation.
Effects of anti-inflammatory dietary education on sleep disturbances among patients with breast cancer undergoing chemotherapy: A randomized controlled trial.
This randomized controlled trial assessed whether anti-inflammatory dietary education could improve sleep and related outcomes in 132 patients with breast cancer, sleep disturbances, and ongoing chemotherapy.
The effect of a stress ball on pain, anxiety, satisfaction, and treatment continuation during extracorporeal shock wave lithotripsy: a randomized controlled trial.
This prospective, two-arm randomized controlled trial assessed whether using a stress ball during extracorporeal shock wave lithotripsy (ESWL) affected pain, anxiety, satisfaction, and continuation among 50 patients…
Exercise modality and planned weekly exercise exposure for motor outcomes in Parkinson's disease: a systematic review, Bayesian network meta-analysis, and meta-regression.
This systematic review and Bayesian network meta-analysis synthesized 173 randomized trials of exercise in people with Parkinson’s disease, assessing motor symptoms, balance, walking speed, and Timed Up and Go (TUG).
Bridging evidence gaps in opioid-sparing postoperative pain control for percutaneous nephrolithotomy: a network meta-analysis identifying optimal strategies.
This systematic review and Bayesian network meta-analysis compared postoperative analgesic strategies in adults undergoing percutaneous nephrolithotomy (PCNL), using randomised controlled trials that assessed pain.
Association of virulence genes with biofilm formation in clinical Enterococcus faecalis isolates: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis assessed associations between virulence gene carriage and microplate-measured biofilm formation in human clinical Enterococcus faecalis isolates.
Robotic systems in cranial surgery: a systematic review of accuracy, clinical outcomes, and adverse events.
This systematic review examined robotic systems used in cranial neurosurgical procedures and their reported accuracy, clinical outcomes, and adverse events.
Tirzepatide-induced pneumatosis intestinalis: a rare but clinically significant gastrointestinal adverse effect.
A 55-year-old man with obesity, type 2 diabetes, hypertension, and obstructive sleep apnea presented with abdominal pain, constipation, and anal fissures while receiving tirzepatide for approximately 1 year; he had lost…
EORTC QLQ-C30 symptom components and their functional correlates during adjuvant chemotherapy for early breast cancer: a multivariate analysis. Data from GEICAM/2003-02 study.
This multivariate analysis of data from a multicentre phase III randomised trial examined changes in EORTC QLQ-C30 symptoms and their relationships with functioning among 820 patients with early breast cancer receiving…
Integrated management of atrial fibrillation with digital health support: a pooled analysis of individual participant data from the mAFA-II and MIRACLE-AF trials.
This pooled individual participant data analysis combined two prospective randomised trials of adults with atrial fibrillation: mAFA-II, which delivered ABC pathway care through a mobile app, and MIRACLE-AF, which used…
Assisted Reproductive Technology and Risk of Congenital Heart Defects in the Offspring: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed congenital heart defect (CHD) risk in offspring conceived through assisted reproductive technology (ART) compared with spontaneous conception.
Body Mass Index, Valsartan, and Myocardial Remodeling in Early-Stage Hypertrophic Cardiomyopathy: A Secondary Analysis of the Randomized VANISH Trial.
This post hoc analysis of the randomized, multicenter VANISH trial examined BMI and cardiac remodeling in participants with early-stage hypertrophic cardiomyopathy. Of 171 participants, 52% had elevated BMI.
Pilot Randomized Trial of 2 Food Purchasing Interventions in Individuals With Hypertension in New Orleans: An American Heart Association Food Is Medicine Initiative.
This randomized pilot trial compared online and in-store food vouchers among 98 people with uncontrolled hypertension in New Orleans.
Omega-6 Polyunsaturated Fatty Acids and Peripheral Artery Disease: An Individual Participant-Level Analysis of 9 International Prospective Studies.
This multicohort individual participant-level analysis and meta-analysis examined baseline omega-6 polyunsaturated fatty acids and incident peripheral artery disease (PAD) among 137,704 participants without clinical PAD…
Genetic Variants in Intracranial Atherosclerotic Disease: A Systematic Review and Targeted Meta-Analysis Highlighting the RNF213 rs112735431.
This systematic review and targeted meta-analysis examined genetic variants associated with intracranial atherosclerotic disease (ICAD) in human studies identified through September 2025.
Efficacy of Tecovirimat for the Treatment of Mpox Virus Infection in Humans: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
This systematic review and meta-analysis assessed tecovirimat efficacy and safety in patients with laboratory-confirmed mpox, comparing it with placebo or standard care in randomised controlled trials.
Disease-Specific Optimal Blood Glucose Control Strategies in Critically Ill Patients: Retrospective Cohort Study and Network Meta-analysis.
This study combined a retrospective MIMIC-IV cohort analysis with a frequentist network meta-analysis of randomized trials to examine glucose-control targets in critically ill patients with sepsis, cardiac disease, or…
Lung ultrasound-guided protocolized fluid management versus conventional central venous pressure-based management in monitoring extravascular lung water during the perioperative period of percutaneous nephrolithotomy: a randomized controlled trial.
This randomized controlled trial compared lung ultrasound (LUS)-guided protocolized fluid management with conventional central venous pressure (CVP)-based management in 181 patients undergoing elective percutaneous…
Detection of MOG-IgG and MOG-IgA in Maternal Breast Milk and Infant Blood in MOGAD: A Case Report.
A mother with MOG antibody-associated disease had persistently elevated plasma MOG-IgG, with a transient decrease in early pregnancy.
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