Trending archive
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1566 articles
October 202624
Outcome assessment in frozen shoulder trials: A systematic review and COSMIN-informed recommendations.
This systematic review mapped outcome measures in 927 randomized controlled trials (RCTs) of frozen shoulder and conducted a COSMIN-informed appraisal of measurement-property evidence for commonly used instruments.
Impact of digital health interventions in improving pediatric immunization coverage and timeliness in low- and middle-income countries: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed randomized controlled trials of digital interventions to improve pediatric vaccination outcomes in low- and middle-income countries.
Implementation of Communication Disability Documentation and Accommodations in Primary Care: A Pragmatic Type III Hybrid Implementation-Effectiveness Trial Protocol.
This article describes the protocol for the DECA study, a pragmatic Type III hybrid implementation-effectiveness trial of communication disability (CD) documentation and accommodation processes in primary care.
Attachment styles and problematic involvement in potentially addictive behaviours: A systematic review and meta-analysis.
This systematic review and meta-analysis examined associations between attachment styles and problematic involvement in behaviours described as addictions, using peer-reviewed studies published before July 23rd, 2026.
40 Hz transcutaneous auricular vagus nerve stimulation enhances verbal free recall in healthy adults by modulating frontal theta oscillations.
This randomized, single-blind, sham-controlled, three-arm trial examined whether 20 Hz or 40 Hz transcutaneous auricular vagus nerve stimulation (taVNS) affected verbal free recall and resting-state EEG theta activity…
Rapid manufactured CAR-T cells enriched for CD45RA-negative T cells exhibit superior persistence compared to conventional CAR-T therapy.
This comparative study evaluated InstanCAR-T, a rapid CD19 CAR-T manufacturing protocol enriched for CD45RA-negative T cells, against conventional CAR-T in laboratory assays, murine B-ALL models, and a Phase I clinical…
Hypofractionated 44 Gy in 20 fractions versus conventional chemoradiation in cervical cancer: 2-year results of the randomized HYPOCx-iRex trial with an exploratory pooled analysis of a single-institute EMBRACE-II cohort.
The randomized HYPOCx-iRex trial compared hypofractionated chemoradiation (44 Gy in 20 fractions) with conventional chemoradiation (45 Gy in 25 fractions) for locally advanced cervical cancer; an exploratory pooled…
Opioid Use and Family Members' Experiences of Opioids in Paediatric Cancer Pain Management: An Integrative Review.
This integrative review analyzed opioid use in pediatric cancer pain management and family members' experiences. Sixteen peer-reviewed articles were reviewed, revealing that morphine and fentanyl are the most commonly…
Irritability in the Mix: An Exploratory Study of the Role of Irritability in Characterising Mood Disorders.
This randomized controlled trial explored the relationship between irritability and mixed states in 82 patients with bipolar disorder over 18 months.
Bipolar Disorder and Perimenopause: An Update.
This systematic review examined the relationship between bipolar disorder (BD) and perimenopause, analyzing 14 studies from various countries.
Effect of a walnut-based low carbohydrate diet on fat redistribution and visceral fat accumulation in people with central obesity: A randomized controlled trial.
This randomized controlled trial investigated the effects of a walnut-based low carbohydrate diet (w-LCD) on fat redistribution and visceral fat accumulation in individuals with central obesity over 12 weeks.
Acute Motor and Sensory Axonal Neuropathy Variant of Guillain-Barré Syndrome: A Nurse-Led Intensive Care Case Report.
A 40-year-old man presented with acute quadriparesis and respiratory distress after a febrile illness. He was diagnosed with acute motor and sensory axonal neuropathy, complicated by multiple infections including…
Giredestrant plus Everolimus in Advanced Breast Cancer.
This phase 3 randomized controlled trial evaluated the efficacy of giredestrant plus everolimus versus standard endocrine therapy plus everolimus in patients with ER-positive, HER2-negative advanced breast cancer who…
Mediation Analysis of Urine Osmolality and Response to Tolvaptan in Autosomal Dominant Polycystic Kidney Disease: A Post Hoc Assessment.
This post hoc analysis of the TEMPO 3:4 randomized controlled trial evaluated urine osmolality (Uosm) as a biomarker for long-term response to tolvaptan in patients with autosomal dominant polycystic kidney disease…
Efficacy and Safety of PD-1/PD-L1 Inhibitors Combined With Anti-Angiogenic Tyrosine Kinase Inhibitors for Recurrent or Metastatic Nasopharyngeal Carcinoma: A Systematic Review and Single-Arm Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy and safety of PD-1/PD-L1 inhibitors combined with anti-angiogenic tyrosine kinase inhibitors in 357 patients with recurrent or metastatic nasopharyngeal…
Hereditary Spastic Paraplegia Type 11: A Comprehensive Case Report.
An 18-year-old woman with no significant medical history presented with a 2-year history of progressive weakness and stiffness in both lower limbs, leading to difficulty in walking.
A Mysterious Case of Giant Scalp Devil's Horn with Intracranial Extension Removed by Surgical Excision.
A 60-year-old male presented with altered consciousness, chronic headaches, blurred vision, and scalp swelling. Imaging revealed a giant cutaneous horn in the scalp with underlying bony erosion and intracranial…
The Urgent Surgical Outcome of Intracranial Subdural Empyema: A Case Presentation.
A patient presented unconscious due to intracranial subdural empyema, a severe brain infection. Urgent surgical intervention was performed, leading to a rapid recovery postoperatively.
Intermittent Pneumatic Compression in Patients with Postmastectomy Lymphedema: A Randomized Controlled Trial.
This randomized controlled trial evaluated the effects of intermittent pneumatic compression (IPC) combined with exercises on upper limb lymphedema in 21 patients post-mastectomy.
Association of Sarcopenia With Global, Motor, Cognitive, and Swallowing Function Prognosis in Stroke Patients: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the impact of sarcopenia on functional outcomes in stroke patients. Analyzing 36 cohort studies, it found that patients with sarcopenia had a significantly higher risk…
Human Infection with Japanese Encephalitis Virus Genotype V, China, 2025.
A human case of Japanese encephalitis virus genotype V (JEV GV) was confirmed in China through serological testing, sequencing, and quantitative reverse transcription PCR.
Chlamydia psittaci Meningitis, Chile, 2023.
A 50-year-old farm worker in Chile presented with meningitis, which was confirmed to be caused by Chlamydia psittaci through cerebrospinal fluid quantitative real-time PCR and serology.
Pharmacokinetic and Pharmacodynamic Drug-Drug Interactions Between Cofrogliptin and Metformin in Healthy Subjects: A Single-Center, Single-Arm, Phase I Study in China.
This single-center, single-arm Phase I study assessed drug-drug interactions between cofrogliptin and metformin in 22 healthy Chinese subjects.
A Phase I Study of Nimotuzumab Combined with Irinotecan in Chinese Patients with Advanced Solid Tumors.
This Phase I study assessed the pharmacokinetics and safety of nimotuzumab combined with irinotecan in Chinese patients with advanced solid tumors.
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