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1566 articles
September 202624
Imaging biomarkers for cardiometabolic risk stratification in metabolic dysfunction-associated steatotic liver disease: incremental value of coronary artery calcification, epicardial adipose tissue, controlled attenuation parameter, and liver stiffness measurement beyond clinical scores.
This systematic review analyzed 16 observational studies involving 34,713 adults with metabolic dysfunction-associated steatotic liver disease (MASLD) to evaluate the association between MASLD and imaging biomarkers of…
Methods for a Community-Engaged Randomized Trial for Urgency Incontinence.
The Beta-Agonist versus ONA Trial for Urgency Urinary Incontinence (BEST) is a multicenter, single-blinded randomized trial comparing the efficacy of beta-agonist medication and onabotulinumtoxinA injections in female…
Uterosacral Versus Sacrospinous Ligament Suspension in Pelvic Organ Prolapse: An RCT.
This randomized controlled trial compared high uterosacral ligament suspension (HUSLS) and sacrospinous ligament fixation (SSF) in women undergoing vaginal hysterectomy for pelvic organ prolapse (POP).
Intracardiac vs. transesophageal echocardiography in patients undergoing ablation for atrial fibrillation: a systematic review and meta-analysis.
This systematic review and meta-analysis evaluated the safety and efficacy of intracardiac echocardiography (ICE) versus transesophageal echocardiography (TEE) in 7671 patients undergoing catheter ablation for atrial…
Age and antiplatelet de-escalation after myocardial infarction in the TALOS-AMI trial.
This secondary analysis of the TALOS-AMI randomized trial evaluated the effects of de-escalating from ticagrelor to clopidogrel on clinical outcomes in patients after myocardial infarction, stratified by age.
Right Brain: Language Without Speech.
During a neurology rotation as a second-year internal medicine resident, I encountered a preschool-aged child whose absence of spontaneous speech initially framed my clinical thinking.
Clinical Reasoning: A 60-Year-Old Woman With Fever, Headache, Diplopia, and Unilateral Periorbital Swelling.
A 60-year-old woman presented with fever, headache, horizontal diplopia, and unilateral periorbital swelling after experiencing recurrent gingival swelling and pain for about a month.
Effectiveness and safety of the available preventive tuberculosis treatment regimens for children and adolescents: systematic review and network meta-analysis.
This systematic review and network meta-analysis evaluated the effectiveness and safety of tuberculosis (TB) treatment regimens in children and adolescents under 18 years.
When seizure control comes at a cost: valproic acid-induced necrotising pancreatitis in a patient receiving antiepileptic polypharmacy.
A man in his late 20s with psychiatric and metabolic comorbidities developed acute necrotising pancreatitis while on antiepileptic polypharmacy, including valproic acid.
Intentional nail ingestion with caecal impaction: colonoscopic removal using a cap-assisted technique.
A woman with a history of recurrent nail ingestion presented with abdominal pain after swallowing multiple nails. Initial conservative management showed progressive migration of the nails, which clustered near the…
Metastatic melanoma presenting with paraneoplastic dermatomyositis mimicking polymyalgia rheumatica.
A man in his late 70s presented with bilateral shoulder and hip girdle pain, morning stiffness, and significant weight loss over six weeks.
Acute variceal bleeding in a patient with phaeochromocytoma: the critical choice of vasoactive therapy.
A woman in her late 70s with a known left-sided phaeochromocytoma experienced acute variceal bleeding, likely due to cirrhosis. Due to the risk of hypertensive crisis, terlipressin was not used.
Lipomatous pseudohypertrophy of pancreas with chronic calcific pancreatitis presenting with nutritional dermatosis and type 3c diabetes.
A woman in her early 50s presented with erythema, scaling of the limbs, weight loss, anasarca, and chronic foul-smelling diarrhea, indicative of nutritional dermatosis due to malabsorption.
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal plasma cell disorder and skin changes) associated with Castleman disease and latent tuberculosis: a diagnostic challenge.
A woman in her 40s presented with progressive multisystem disease, including chronic distal neuropathy, constitutional decline, lymphadenopathy, and serosal effusions.
Masked polycythaemia vera presenting with extensive splanchnic venous thrombosis and mesenteric ischaemia.
A woman in her 60s with masked polycythaemia vera (PV) presented with extensive splanchnic venous thrombosis and mesenteric ischaemia after 5 years of management with phlebotomy and aspirin.
Marjolin's ulcer developing in a post-traumatic scar: management with negative pressure wound therapy and split-thickness skin grafting.
A man in his 60s presented with a large, non-healing ulcer at the site of a traumatic injury and reconstructive surgery from three decades prior.
Saprochaete pneumonia presenting as septic shock in an elderly patient with poorly controlled diabetes mellitus.
An elderly woman with poorly controlled diabetes presented with community-acquired pneumonia, septic shock, and multi-organ dysfunction. Despite initial antibiotic treatment, her condition deteriorated.
Metastatic muscle invasive bladder cancer in pregnancy.
A woman in her 30s presented during the second trimester with hematuria and left flank pain. MRI identified a T3b bladder tumor with suspected peritoneal invasion.
Anakinra versus intramuscular methylprednisolone acetate for gout flares in people with chronic kidney disease (ASGARD): a UK randomised multicentre, double-blind, double-dummy controlled feasibility study with economic, qualitative and safety assessment.
The ASGARD study was a feasibility randomized controlled trial comparing anakinra to intramuscular methylprednisolone acetate for treating gout flares in patients with chronic kidney disease.
Performing lifestyle changes and reducing stroke risk: a process evaluation of a stroke prevention intervention.
This randomized controlled trial evaluated a stroke prevention intervention in Swedish primary healthcare, focusing on implementation processes and mechanisms of change among 122 high-risk participants.
Effectiveness of psychosocial counselling on treatment adherence among patients with a new tuberculosis diagnosis in primary care: a study protocol for a cluster-randomised controlled trial.
This study protocol outlines a cluster-randomised controlled trial aimed at evaluating the effectiveness of psychosocial counselling on treatment adherence among newly diagnosed tuberculosis patients in primary care…
Implementing a medical opinion leader-led management model to promote timely treatment initiation among screen-positive patients with upper gastrointestinal cancer in rural China: a cluster randomised controlled trial protocol.
This cluster randomised controlled trial aims to assess the effectiveness of a medical opinion leader-led management model in reducing treatment initiation time for screen-positive upper gastrointestinal cancer patients…
Association between personal birth companion and maternal mental health in low- and middle-income countries: a systematic review.
This systematic review examined the impact of personal birth companions on maternal mental health during labor and postpartum in low- and middle-income countries.
Behavior Change and Compliance Outcomes of a Novel Web-Based Health Behavior Tool Integrated Into Certified Exercise Practitioner Services: Twelve-Week, Two-Arm, Randomized Pre-Post Trial.
This randomized controlled trial evaluated the impact of a web-based health behavior tool, the FESS questionnaire, on health behaviors in 41 older adults (median age 65) receiving services from certified exercise…
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