Trending archive
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1696 articles
October 202620
Preoperative High-Dose Corticosteroids in Digestive Cancer Surgery: A Randomized Clinical Trial.
This multicenter, double-blind, placebo-controlled superiority randomized trial assessed whether preoperative high-dose corticosteroids improve outcomes after elective, curative-intent surgery for digestive cancer.
Bimekizumab efficacy in male and female patients with axial spondyloarthritis: 52-week results from the phase 3 BE MOBILE trials.
This post hoc analysis of two phase 3 randomised trials assessed sex-based differences in bimekizumab response among patients with radiographic or non-radiographic axial spondyloarthritis.
Psychological Interventions Targeting Auditory Hallucinations in Persons With Psychotic Disorders: A Systematic Review and Meta-Analysis.
This systematic review and random-effects meta-analysis assessed randomised trials of psychological and psychosocial interventions targeting auditory hallucinations in adults with schizophrenia spectrum disorders.
Social Determinants of Health and Neurobiology Across the Schizophrenia Course: A Systematic Review.
This systematic review examined associations between adverse social determinants of health and brain measures in people across the schizophrenia spectrum, including those at elevated risk.
Dose Considerations and Generalization Following Script Training for Poststroke Aphasia: A Randomized Factorial Clinical Trial.
This single-site, single-blind, 2 × 2 factorial randomized controlled trial examined how script length and session frequency affect treatment outcomes in 85 people with chronic poststroke aphasia.
Online stepped care for the treatment of posttraumatic stress disorder: A randomized controlled noninferiority trial.
This randomized controlled non-inferiority trial compared online stepped care with telehealth cognitive processing therapy (CPT) in 84 adults with PTSD or subthreshold PTSD.
Who is getting better in treatment? Dynamics in risk processes as a signature of short-term suicide treatment response.
This analysis of adults receiving up to 12 sessions of suicide-focused therapy within a randomized clinical trial examined whether weekly patterns in suicide risk and resilience differed according to suicide attempts…
Sensory processing and executive functioning interaction in neurodevelopmental disorders and at-risk conditions: A systematic review and meta-analysis.
This systematic review and meta-analysis examined associations between sensory processing (SP) and executive functioning (EF) in children and adolescents aged 0–18 with neurodevelopmental disorders or at-risk…
Persistent influenza A RNA detection in a fatal pediatric case of influenza-associated encephalopathy.
A 9-year-old boy developed fulminant influenza-associated encephalopathy, a life-threatening complication of influenza. Despite life-sustaining support, intensive immunomodulatory treatment, and antiviral therapy…
Oral peri-implant tissue as a neoplastic bed: a systematic review of clinicopathology, pathogenesis, and survival outcomes.
This systematic review assessed the clinicopathology, associated factors, and survival outcomes of histologically confirmed neoplasms adjacent to dental implants.
Envenomation by a Razi's viper, Macrovipera razii (Serpentes: Viperidae) in Iran: A neglected public health threat, report of two cases, and clinical implications.
Two men in Iran developed severe local injury after bites from Macrovipera razii. A 36-year-old man bitten on a finger received six vials of polyvalent antivenom but developed progressive necrosis, leaving permanent…
Positive emotions and credibility: Understanding how a community-engaged online campaign featuring clinician testimonials improved rural vaccine promotion.
This four-arm randomized survey experiment tested the community-engaged Communities Confronting COVID-19 campaign among 1,364 rural U.S. residents.
Davos@home: Integrating objective home monitoring into eHealth self-management support after alpine altitude climate treatment for severe asthma.
This 12-month pragmatic randomised trial assessed whether objective home monitoring adds benefit to eHealth self-management after Alpine Altitude Climate Treatment (AACT) in adults with severe asthma.
Systematic Review: Inclusion of Patients With Difficult-to-Treat Inflammatory Bowel Disease in Randomized Controlled Trials of Advanced Therapies.
This systematic review examined how patients with difficult-to-treat inflammatory bowel disease (DTT-IBD) were represented in randomized controlled trials of advanced therapies for ulcerative colitis and Crohn’s…
Exceptional and Durable Response to Selpercatinib in a Patient with Apparently RET -Negative, HRAS -, and NF1 -Mutated Metastatic Medullary Thyroid Carcinoma.
A 50-year-old woman presented with rapidly progressive medullary thyroid carcinoma (Ki-67 30%) and extensive liver and bone metastases.
Clinical trial: The Effect on Intragastric pH and Pharmacokinetics of the PCAB Linaprazan Glurate in Healthy Subjects After Repeat-Dose Administration for up to 14 Days.
This open, randomised, parallel-group Phase 1 trial assessed intragastric pH and pharmacokinetics after single and repeated linaprazan glurate (LG) dosing in 73 healthy subjects.
Effects of sprint interval training on markers of metabolic health: A three-level meta-analysis of randomised controlled trials.
This systematic review and three-level meta-analysis examined randomised controlled trials comparing sprint interval training (SIT) with no-exercise control or moderate-intensity continuous training (MICT) for metabolic…
Updated Meta-Analysis of Left Atrial Appendage Closure Versus Oral Anticoagulation to Prevent Stroke in Atrial Fibrillation.
This systematic review and meta-analysis pooled six randomized controlled trials comparing percutaneous left atrial appendage closure (LAAC) with oral anticoagulation in 7028 patients with nonvalvular atrial…
The predictive value of early-pregnancy mean platelet volume for preeclampsia: A meta-analysis.
This meta-analysis assessed whether mean platelet volume (MPV) measured before 20 weeks’ gestation is associated with subsequent preeclampsia.
Feasibility of using Making Mindfulness Matter© for children with epilepsy and their parents: A pilot randomized controlled trial.
This parallel, 1:1 pilot randomized controlled trial assessed whether an eight-week, live-online family mindfulness program could be delivered to children with epilepsy aged 4–10 years and their parents in Ontario…
September 20264
Continuous Intravenous Acyclovir as Outpatient Parenteral Antimicrobial Therapy for HSV and VZV Neurological Infections: A Case Series With Pharmacokinetic and Cost Evaluation, and Review of Literature.
This case series involved eight patients with neurological infections caused by HSV or VZV who transitioned to continuous intravenous acyclovir via an outpatient parenteral antimicrobial therapy (OPAT) program after…
Impact of EBV status and histology on patient outcomes with nivolumab-AVD vs BV-AVD in advanced classic Hodgkin lymphoma (S1826).
This phase 3 randomized controlled trial evaluated the impact of EBV status and histology on outcomes in patients with advanced classic Hodgkin lymphoma treated with nivolumab-AVD (N-AVD) versus brentuximab vedotin-AVD…
A phase 1/1b study of the all-oral regimen CC-486 and venetoclax in acute myeloid leukemia.
This phase 1/1b study evaluated the all-oral regimen of CC-486 and venetoclax in patients with relapsed, refractory, and newly diagnosed acute myeloid leukemia (AML).
A phase 1b/2 study of ceralasertib, a selective inhibitor of ATR, in patients with relapsed or refractory MDS and CMML.
This phase 1b/2 study evaluated ceralasertib, an ATR inhibitor, in 44 adults with relapsed or refractory MDS and CMML. The overall response rate was 29.5%, with a median progression-free survival of 4.8 months and…
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