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1557 articles
October 202624
Translational applications and clinical utility of organoids in ovarian cancer: a systematic review.
This systematic review synthesized 13 studies of patient-derived organoids (PDOs) in ovarian cancer, assessing feasibility, histological fidelity, and agreement between organoid drug sensitivity and clinical outcomes.
Novel Imaging Techniques Prior to Surgical Management of Invasive Bladder Cancer: A Systematic Review.
This PRISMA-guided systematic review assessed novel imaging for detecting muscle invasion and nodal disease before surgical management of invasive bladder cancer. It included 33 studies encompassing 4,689 patients.
A case of lysozyme-induced nephropathy with improved renal function following treatment for chronic myelomonocytic leukemia.
A 75-year-old man with longstanding diabetes presented with weight loss and progressive anemia and was diagnosed with chronic myelomonocytic leukemia (CMML).
Determining the minimal important difference of EQ-5D-5 L utility values in CIDP patients using data from a large clinical trial.
This analysis of data from the ADHERE randomized controlled trial estimated the minimal important difference (MID) in EQ-5D-5 L utility values for patients with chronic inflammatory demyelinating polyradiculoneuropathy…
Patients with MASH experience worse health-related quality of life: a multinational real-world study using LiverMultiScan.
This multinational real-world randomised controlled trial examined health-related quality of life (HRQoL) and liver MRI markers in 802 people with suspected MASLD/MASH across four European countries.
Clinical and radiographic success of bioflex versus stainless steel crowns using the hall technique in primary molars: a 12-month randomized controlled trial.
This two-arm randomized controlled trial compared BioFlex crowns (BFCs) with stainless-steel crowns (SSCs), both placed using the Hall Technique, in healthy children aged 4–6 years with carious mandibular second primary…
Locus coeruleus abnormalities on neuromelanin-sensitive MRI in Parkinson's disease: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed locus coeruleus (LC) integrity on neuromelanin-sensitive MRI in Parkinson’s disease (PD), pooling independent comparisons with healthy controls using random-effects…
Efficacy and Safety of Argatroban as an Adjunct to Antiplatelet Therapy in Ischemic Stroke: An Updated Systematic Review and Meta-analysis.
This systematic review and meta-analysis assessed argatroban added to antiplatelet therapy versus control in acute ischemic stroke.
Effectiveness of tocilizumab monotherapy for IgG4-related disease-like features caused by idiopathic multicentric Castleman's disease: a case-based review.
A 68-year-old woman presented with dyspnea associated with a recurrent laryngeal tumor, pulmonary consolidation, mediastinal and axillary lymphadenopathy, sclerosing mesenteritis, and retroperitoneal fibrosis.
Clinical safety, tolerability, and efficacy of fospropofol disodium for sedation: a systematic review.
This systematic review and meta-analysis assessed randomized trials of fospropofol for procedural and ICU sedation. It included 10 studies: six procedural-sedation trials and four ICU-sedation trials.
Minimally invasive management of pulmonary artery bleed in robotic left upper lobectomy.
A patient undergoing robotic left upper lobectomy for a Pancoast tumour developed an intraoperative pulmonary artery bleed.
Hyponatremic-Hypertensive Syndrome as a Rare Manifestation of Renovascular Hypertension: A Case Series.
Two girls, aged 4 and 9 years, presented with severe hypertension and electrolyte disturbances, including hyponatremia and hypokalemia, with elevated renin-aldosterone activity.
Clinical Outcomes and Complications of Extracorporeal Membrane Oxygenation (ECMO) in Adult Patients With COVID-19 in Central and Eastern Europe: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled observational studies of adults with COVID-19 treated with ECMO in Central and Eastern Europe. Twelve studies covered 802 patients from six countries.
Concurrent administration of BCMA and GPRC5D CAR T cells for advanced multiple myeloma.
This phase 1 dose-escalation trial evaluated BCMA-directed CAR T-cell therapy MCARH125 alone or infused concurrently with GPRC5D-directed MCARH109 in patients with relapsed or refractory multiple myeloma.
Silver diamine fluoride versus conventional restorative treatment for dental caries in primary teeth of children: a meta-analysis.
This meta-analysis compared 30% to 38% silver diamine fluoride (SDF) with conventional restorative approaches for caries control in children with carious primary teeth.
Effects of transcranial direct current stimulation on nicotine use disorder: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed transcranial direct current stimulation (tDCS) for smoking-related outcomes in people with nicotine use disorder.
Clinical performance of resin infiltration and different sealant modalities in noncavitated pits and fissures: a split-mouth randomized controlled trial.
This split-mouth randomized controlled trial compared resin infiltration, two sealant approaches, and their combination for noncavitated occlusal lesions in 128 permanent molars from 32 children aged 7–14 years.
Effects of exposure to negative and positive social media content about vaping and nicotine addiction on beliefs and intentions to use e-cigarettes among young adults in the United States: results from a randomized controlled experiment.
This randomized controlled experiment assigned 1,816 young adults in the United States to view real, publicly accessible social media videos presenting nicotine addiction positively, negatively, or in unrelated control…
Anbalcabtagene autoleucel (PD-1 and TIGIT knockdown CD19 CAR T-cell therapy) for relapsed or refractory LBCL: the CRC01-01 trial.
The multicenter phase 1/2 CRC01-01 trial evaluated anbalcabtagene autoleucel, a CD19 CAR T-cell therapy with PD-1 and TIGIT knockdown, in patients with relapsed or refractory large B-cell lymphoma.
A self-controlled case series to evaluate the effects of clinical trial eligibility criteria on biologic-associated reductions in severe asthma exacerbations: an analysis of the CHRONICLE study.
This study examined whether eligibility criteria used in biologic trials identify adults with severe asthma who are more likely to benefit.
Avatar-led digital health intervention for sexual and gender minority young adult smoking cessation: randomized controlled pilot trial.
This randomized controlled pilot trial compared EQQUAL, an Acceptance and Commitment Therapy-based digital smoking cessation program tailored for sexual and gender minority (SGM) young adults, with Smokefree.gov.
Randomized controlled trial of a group-based smoking cessation intervention for adults with serious mental illness.
This randomized controlled trial evaluated PARQuit in 99 adults with serious mental illness in the United States. Participants received 12 weeks of cessation counseling and pharmacotherapy and were assigned to…
Combined Chatbot and Counselor Support for Smoking Cessation in China: A Pilot, Mobile-Based, Randomized Controlled Trial.
This two-arm, community-based randomized pilot trial in China assessed chatbot-supported smoking cessation and whether adding personalized counselor support might improve outcomes.
Firstline treatment with ruxolitinib versus best available therapy in patients with polycythemia vera: results from the randomized RuxoBEAT trial.
The multicenter randomized RuxoBEAT trial compared first-line ruxolitinib (RUX) with best available therapy (BAT) in patients with polycythemia vera.
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