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1313 articles
October 202624
First-in-Human Phase 1b/2a Trial Shows Safety with MEK 1/2 Inhibitor EDV2209 as A Novel Treatment for Spontaneous Subarachnoid Hemorrhage.
The STOP-DCI first-in-human Phase 1b/2a interventional, randomized, double-blind, placebo-controlled trial evaluated intracerebroventricular EDV2209, a MEK 1/2 inhibitor, in patients with severe spontaneous subarachnoid…
Survival Outcomes in Metastatic Colorectal Cancer Patients with BRAF Mutations Undergoing Targeted Chemotherapy: A Reconstructed Individual Patient Data Meta-Analysis of Randomized Controlled Trials.
This reconstructed individual patient-data meta-analysis of 18 randomized controlled trials examined survival outcomes across targeted treatment classes in BRAF V600E-mutant metastatic colorectal cancer.
Treatment Procedures for the Edentulous Maxilla: Supplement Report for the First Global Consensus for Clinical Guidelines (GCCG).
The report describes clinical rehabilitation of an edentulous maxilla using implant-supported restorations. It applies the treatment-procedures component of the First Global Consensus for Clinical Guidelines (GCCG)…
Treatment Procedures in the Rehabilitation of the Edentulous Maxilla with an Implant- Supported Fixed Dental Prosthesis-A Case Report.
An edentulous patient underwent rehabilitation of the maxillary arch with an implant-supported fixed dental prosthesis. The report presents the treatment procedures in the context of Global Consensus for Clinical…
Sexual dimorphism and age effects in CKD and type 2 diabetes in the CONFIDENCE trial.
This analysis of the randomized CONFIDENCE trial examined age- and sex-related differences in urinary albumin-to-creatinine ratio (UACR) changes among people with type 2 diabetes and chronic kidney disease receiving…
Acute declines in kidney function with thiazide plus loop diuretics versus loop diuretics alone in acute decompensated heart failure.
This analysis of the randomized CLOROTIC trial examined whether early eGFR changes were associated with outcomes in patients admitted with acute decompensated heart failure and randomized to thiazide or placebo…
Prehospital Analgesia in Trauma: A Systematic Review of Current Evidence.
This systematic review assessed the safety and effectiveness of pharmacologic analgesia given before hospital arrival to acutely injured adults aged over 15 years.
A Systematic Review and Meta-Analysis of Randomized Clinical Trials Comparing the Effectiveness of Corticosteroid Injection Versus Night Splints in Patients With Carpal Tunnel Syndrome.
This systematic review and meta-analysis of randomized controlled trials compared corticosteroid injection (CSI) with night splinting (NS) for carpal tunnel syndrome.
Effects of Walnut Consumption on Inflammatory Cytokines and Adipokines in Adults: A Systematic Review and Dose-Response Meta-Analysis.
This systematic review and dose-response meta-analysis assessed randomized trials of walnut intake and inflammatory cytokines and adipokines in adults.
Hypothalamic Neurochemical and Microglial Suppression in Long-Standing Human Hibernation-Like Syndrome.
A 57-year-old woman had a more than 30-year history of winter-associated hypothermia, neuroendocrine instability, psychomotor suppression and circannual rhythmicity.
A rare cause of postpartum hemoperitoneum: Uterine laceration secondary to sustained transabdominal uterine massage following vaginal delivery: A case report.
After vaginal delivery, a patient with an unscarred uterus developed postpartum hemorrhage from uterine atony and was treated with uterotonics and transabdominal uterine massage.
Cutaneous clues: Malignant acanthosis nigricans and tripe palms as first signs of recurrent endometrial carcinoma.
A 73-year-old woman, disease-free for six years after treatment of stage IB endometrial endometrioid adenocarcinoma, developed acanthosis nigricans and tripe palms.
A pilot study of electromagnetic therapy versus biofeedback-based pelvic floor muscle training for pelvic organ prolapse: A mixed-methods approach.
This mixed-methods pilot randomised trial compared high-intensity focused electromagnetic (HIFEM) therapy, supervised pelvic floor muscle training (PFMT) with biofeedback and/or electrostimulation, and usual care in…
The Effects of Mind-Body Exercise on Cognitive Function and Peripheral Blood BDNF in Elderly People With Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled 17 randomized controlled trials involving 1,251 older adults with mild cognitive impairment to assess mind-body exercise and cognition and peripheral blood BDNF.
The Effect of Using Heated IV Fluids With Underbody Warmers on Maternal and Neonatal Well-Being in Cesarean Delivery Operations: A Randomized Clinical Trial.
This randomized clinical trial at a university hospital compared underbody warming alone, underbody warming plus heated IV fluids, and passive blanket heating in 105 pregnant patients undergoing cesarean delivery.
Effectiveness of a Ceramide-Based Lamellar Emulsion on Skin Barrier Function in Surgical Nurses: A Randomized Controlled Trial.
This single-center randomized controlled trial assessed whether a ceramide-based lamellar emulsion improved hand skin barrier function in surgical nurses exposed to frequent perioperative hand hygiene.
Effects of a Multicomponent App-Based Exercise Program on Motor Skill Development in Children With Attention Deficit Hyperactivity Disorder: A Secondary Outcome Analysis of a Three-Arm Randomized Controlled Trial.
This secondary outcome analysis of a three-arm randomized controlled trial assessed motor skills in 145 children aged 6–10 years with ADHD.
PIH1D2 Loss-of-Function Directs Ciliary and Cell Cycle Defects Resulting in Left Isomerism With or Without Biliary Atresia.
Two unrelated patients with left isomerism heterotaxy were found by genome sequencing to have biallelic loss-of-function variants in PIH1D2.
Efficacy of High-Frequency Transcranial Magnetic Stimulation Therapy for Depression With Insomnia Symptoms: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials.
This systematic review and meta-analysis of randomized controlled trials assessed left dorsolateral prefrontal cortex-targeted high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) for people with…
Secondary Syphilis.
A 46-year-old man presented with two months of progressive, painful visual loss. Examination showed bilateral panuveitis alongside widespread ulcerative skin lesions and alopecia.
From Daily Attitudes to Alcohol-Related Harm: A Within-Person Serial Mediation Test Informed by the Theory of Planned Behavior.
This multilevel daily-diary study examined whether day-to-day changes in attitudes toward heavy drinking were linked to alcohol-related harm through intentions and consumption.
Curative-intent management of de novo metastatic nasopharyngeal carcinoma: an evidence-based consensus guideline from the International Collaborating Oncology Organisations.
This international consensus guideline addresses curative-intent management of de novo metastatic nasopharyngeal carcinoma, a population historically treated with palliative intent.
Polycystic ovary syndrome research in sub-Saharan Africa: a systematic review on current status and future directions.
This systematic review assessed original research on polycystic ovary syndrome (PCOS) in sub-Saharan African populations, searching four databases through 9 August 2026.
Is plant-based protein supplementation as effective as whey protein? A systematic review and meta-analysis in untrained adults undergoing resistance training.
This systematic review and meta-analysis compared plant-based with whey protein supplementation for body composition in untrained adults aged 18–59 years undertaking resistance training.
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