Trending archive
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1313 articles
October 202624
Impact of Chatbot-Based Cognitive Training on Cognitive Function and White Matter Integrity in Cognitively Unimpaired Older Adults: Randomized Controlled Trial.
This single-blind randomized controlled trial evaluated chatbot-based cognitive training in 72 cognitively unimpaired older adults.
Neck-Specific Exercises With Internet Support Versus Standard Neck-Specific Exercise for the Treatment of Chronic Whiplash-Associated Disorders: Cost-Effectiveness Analysis.
This prospective, multicenter randomized controlled trial compared a 3-month internet-supported neck-specific exercise program plus four physiotherapy visits (NSEIT) with clinic-based neck-specific exercise twice weekly…
Mind Your Heart-A Web-Based Dietary Approaches to Stop Hypertension Diet and Mindful Eating Intervention for Working Adults at Elevated Cardiovascular Risk: Pilot Randomized Controlled Trial.
This pilot randomized controlled trial assessed the feasibility and preliminary effects of a six-week, self-guided web-based DASH education program, with or without mindful eating instruction, among working adults at…
B cell subsets are associated with durable responses in distinct cancer types after immune checkpoint inhibition.
This study examined B-cell responses and outcomes after immune checkpoint inhibition, combining a prospective randomized phase 2 trial of 106 patients with single-cell profiling of intratumoral B cells from 152 patients…
Dengue virus controlled human challenge reveals that preexisting immunity shapes viral replication and broadly protective responses.
This phase 1 controlled human challenge trial enrolled 45 healthy adults to examine how preexisting immunity shapes responses to heterotypic dengue virus challenge.
Multimedia versus audio-based education for improving dentists' nutrition-related knowledge and behavior: A randomized comparative study.
This randomized comparative trial assessed whether multimedia or audio-based education improved nutrition-related knowledge and self-reported behavior among 166 general dentists in Tehran.
Bilateral Iatrogenic Pneumothorax After Acupuncture in a 26-Year-Old Woman Presenting With Cough, Pleuritic Chest Pain, and Tachycardia: A Case Report.
A 26-year-old woman presented two days after trapezius-region acupuncture with persistent cough, pleuritic chest pain, and difficulty taking a full breath; she had coughed during the needling.
Emergency thoracoabdominal aortic repair: distal-first approach with two previous aortic repairs.
A 59-year-old man with preoperative haemodialysis and two prior aortic repairs—a frozen elephant trunk for acute type A dissection and subsequent thoracic endovascular repair—presented with chest pain.
Patient-reported outcome measures for depressive symptoms in adults with spinal cord injury: a COSMIN systematic review.
This COSMIN systematic review assessed patient-reported measures of depressive symptoms in adults with traumatic or non-traumatic spinal cord injury.
HHV-6 Encephalitis Presenting With Severe SIADH and CO₂ Narcosis in Non-Transplant Smoldering Adult T-Cell Leukemia/Lymphoma.
A 55-year-old woman with smoldering adult T-cell leukemia/lymphoma (ATLL), treated with systemic corticosteroids for suspected HTLV-1-associated uveitis, was admitted with pulmonary infection.
Postoperative membranous urethral length and continence recovery after robot-assisted radical prostatectomy: a Bayesian longitudinal meta-analysis.
This PROSPERO-registered systematic review and Bayesian longitudinal meta-analysis examined whether postoperative MRI-measured membranous urethral length (MUL) was associated with urinary continence recovery after…
Effect of photobiomodulation on recovery from oral soft tissue local anaesthesia in paediatric patients: a preliminary split-mouth randomized clinical trial.
This preliminary split-mouth randomized clinical trial assessed whether 810-nm diode laser photobiomodulation (PBM) shortened oral soft-tissue anaesthesia after infiltration local anaesthesia in 34 children aged 8–12…
Robot-assisted versus conventional cranial stereotactic neurosurgery: a systematic review and meta-analysis of targeting accuracy, procedural efficiency, and safety.
This systematic review and meta-analysis compared robot-assisted with conventional cranial stereotactic neurosurgery across 21 comparative studies, examining targeting accuracy, procedural efficiency, safety and…
Home-based nurse-led self-management support for heart failure: a randomized controlled trial.
This parallel-group randomized controlled trial assessed a 12-week, nurse-led home programme of tailored self-management support and follow-up for adults aged 40–75 years with NYHA class I–III heart failure and ejection…
Treatment of Crimean-Congo Hemorrhagic Fever With Supportive Care, Favipiravir, and Avatrombopag.
A patient with severe Crimean-Congo hemorrhagic fever was managed in a high-level isolation unit with supportive care, favipiravir, and avatrombopag.
Long-term impact of aficamten on patient-reported outcome measures in obstructive hypertrophic cardiomyopathy: results from FOREST-HCM.
This open-label extension study assessed longer-term patient-reported outcomes with aficamten in people with obstructive hypertrophic cardiomyopathy who had completed an aficamten trial.
Catheter ablation in end-stage heart failure with atrial fibrillation: an hierarchical endpoint analysis of the CASTLE-HTx trial.
This ancillary hierarchical endpoint analysis of the multicentre randomized CASTLE-HTx trial compared catheter ablation plus guideline-directed medical therapy (GDMT) with medical therapy alone in 194 patients with…
A NETwork meta-analysis with COST-effectiveness evaluation of pharmacological treatments for heart failure with reduced ejection fraction: NET-COST-HFrEF.
This network meta-analysis of 47 randomized controlled trials involving 75,978 patients with heart failure with reduced ejection fraction assessed guideline-directed drug combinations and their cost-effectiveness.
Subgroup Analysis of Pooled Phase 3 Efficacy Data From Two Randomized Trials of Gepotidacin Versus Nitrofurantoin in Uncomplicated Urinary Tract Infections (EAGLE-2 and EAGLE-3) Including Participants With Uropathogens Not-Susceptible to Nitrofurantoin.
This pooled subgroup analysis of two phase 3 randomized trials compared gepotidacin with nitrofurantoin in female participants aged ≥12 years with uncomplicated urinary tract infections.
Treatment of Progressive Multifocal Leukoencephalopathy With Third-Party Allogeneic BK Virus T Cells.
This single-center phase 2 study evaluated third-party, partially HLA-matched BK virus-specific T cells in 37 patients with progressive multifocal leukoencephalopathy (PML), including 23 with hematologic malignancy.
Proof-of-Concept Phase 2a Trial of VH4524184: An Emerging Third-Generation Integrase Strand Transfer Inhibitor With an Enhanced Resistance Profile.
This randomized, double-blind, placebo-controlled phase 2a trial assessed short-course oral VH-184 monotherapy in adults with HIV-1 who were antiretroviral-therapy naive and had HIV-1 RNA ≥ 3000 copies/mL.
Immunogenicity and Safety of Coadministration of AS01E-Adjuvanted Respiratory Syncytial Virus Prefusion F Protein Vaccine and a COVID-19 mRNA Vaccine in Adult s Aged ≥50 Years: A Phase 3, Randomized, Noninferiority Trial.
This phase 3, open-label, multicenter randomized noninferiority trial compared coadministration of an AS01E-adjuvanted RSV prefusion F vaccine and an Omicron XBB.1.5 COVID-19 mRNA vaccine with administration…
SARS-CoV-2 Vaccination and Attenuation of Breakthrough Infection Severity: A Systematic Global Review and Meta-analysis.
This systematic review and meta-analysis examined whether COVID-19 vaccination attenuates disease severity among people with breakthrough infections, using global observational studies reporting matched…
Performance of prediction models for incident heart failure and heart failure hospitalization in individuals with type 2 diabetes: a systematic review and meta-analysis.
This systematic review and Bayesian meta-analysis assessed multivariable models predicting incident heart failure (HF) or HF hospitalization (HFH) in people with type 2 diabetes.
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